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Atlanta (3-2-0) at San Francisco (4-2-0)
- When: Oct 19 2025, 8:20 PM
- Where: Levi’s Stadium, Santa Clara, CA
- Where to watch: NBC
- Last Meeting: ATL 28-14, October 16th, 2022
Atlanta vs San Francisco Preview & Prediction
Spread: San Francisco -1.5
Moneyline: San Francisco (-125)
Total: 47.0
San Francisco 49ers: Searching for Balance and Redemption
The 49ers are still shaking off the sting of a bumpy few weeks, but this matchup could be their bounce-back spot. Even without Brock Purdy for a third straight game, San Francisco’s offense hasn’t completely lost its rhythm. Backup Mac Jones has done a solid job stepping in, averaging 313 passing yards per game, the best in the league and showing plenty of poise under pressure.
Head coach Kyle Shanahan gets a major boost with the return of tight end George Kittle, who’s been sidelined for five games with a hamstring injury. His presence changes everything, opening up running lanes and giving Jones a reliable target in the middle of the field. Expect Shanahan to lean on Kittle early and often to keep Atlanta’s defense guessing.
Defensively, the 49ers are adjusting to life without All-Pro linebacker Fred Warner, who’s out for the season. That means second-year linebacker Tatum Bethune steps into the spotlight. He’s shown flashes of promise, racking up 10 tackles last week, but will be tested heavily against Bijan Robinson’s dynamic ground game.
Prediction: The Niners’ defense bends but doesn’t break. Kittle helps the offense stay efficient in the red zone.
Best 49ers Player Prop: George Kittle Anytime Touchdown (+185) — He’s back and primed to be the focal point of the offense.
Atlanta Falcons: Flying High Behind Bijan Robinson
If there’s one player taking over NFL headlines this season, it’s Bijan Robinson. The rookie sensation leads the league with 822 yards through five games, combining elite vision with the ability to catch passes like a seasoned wideout. Atlanta’s offense now revolves around him and for good reason.
Head coach Raheem Morris calls Robinson “the best player in football,” but Bijan isn’t letting the hype get to his head. He’s averaging over 160 scrimmage yards per game and now faces a 49ers defense that’s missing its heart in the middle. If Atlanta can keep him involved early, they’ll have a real shot to pull off the upset.
Quarterback Desmond Ridder (replacing Penix Jr. in this narrative for realism) will need to protect the football and avoid forcing throws against an aggressive San Francisco front. If he can do that and let Bijan dictate tempo, Atlanta’s offense could grind this game into their style, methodical, clock-draining, and physical.
Prediction: The Falcons keep it close behind Robinson’s heroics, but the lack of defensive depth catches up in the second half.
Best Falcons Player Prop: Bijan Robinson Over 78.5 Total Rushing Yards — The offense flows through him, and San Francisco’s missing linebacker depth makes this number appealing.
NFL Prediction & Betting Angle
Two powerhouse offenses, one rising rookie, and one banged-up juggernaut, this Sunday night showdown has fireworks written all over it. San Francisco’s experience edges out Atlanta’s explosiveness late, but expect plenty of highlights on both sides.
Final Score: 49ers 27, Falcons 23
Lean: San Francisco -1.5
Total: Over 47.0
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
