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Super Bowl Contenders Meet as Bills, Rams Open 2022 NFL Season

The fans at SoFi Stadium will be treated to a game between the Buffalo Bills and the Los Angeles Rams when they take their seats on Thursday.

(Photo by Cooper Neill/Getty Images) Matthew Stafford

NFL Matchup: Buffalo Bills @ Los Angeles Rams
When: 8:20 PM ET, Thursday, September 8, 2022
Where: SoFi Stadium, Inglewood, California
Where to watch: NBC

Buffalo Bills @ Los Angeles Rams
Point Spread

Buffalo Bills   -2.5 (-110)
Los Angeles Rams   2.5 (-110)

Buffalo Bills @ Los Angeles Rams
Total

Over   52.0 (-115)
Under   52.0 (-105)

Buffalo Bills @ Los Angeles Rams
Moneyline

Buffalo Bills   -135
Los Angeles Rams   +115

Passing Team Leaders:
Buffalo Bills: Josh Allen 4407 Yds
Los Angeles Rams: Matthew Stafford 4886 Yds

The Los Angeles Rams are eager to start defense of their Super Bowl crown, while the Buffalo Bills are focused on reaching the big game for the first time since the 1993 season.

The two teams begin pursuit of their season goals when the NFL season kicks off Thursday night at Inglewood, Calif.

"It’ll be a big challenge for us," Bills coach Sean McDermott said. "They’re the defending Super Bowl champs, (and) at their place, so we’ve got to play good team ball."

The Rams went 12-5 in the regular season last year before going on to secure a 23-20 victory over the Cincinnati Bengals in their home stadium in the Super Bowl.

2025 Super Bowl LIX Odds

Betting Odds Trends

Los Angeles Rams
LA Rams is 2-4 ATS in its last 6 games
LA Rams is 9-1 SU in its last 10 games
The total has gone UNDER in 4 of LA Rams’s last 6 games
LA Rams is 4-1 SU in its last 5 games at home
The total has gone UNDER in 6 of LA Rams’s last 7 games at home
LA Rams is 1-4 ATS in its last 5 games when playing Buffalo
LA Rams is 1-4 SU in its last 5 games when playing Buffalo
The total has gone OVER in 8 of LA Rams’s last 9 games when playing Buffalo
Buffalo Bills
Buffalo is 4-1-1 ATS in its last 6 games
Buffalo is 5-1 SU in its last 6 games
The total has gone OVER in 5 of Buffalo’s last 7 games
The total has gone OVER in 4 of Buffalo’s last 5 games on the road
Buffalo is 4-1 ATS in its last 5 games when playing LA Rams
Buffalo is 4-1 SU in its last 5 games when playing LA Rams
The total has gone OVER in 8 of Buffalo’s last 9 games when playing LA Rams

NFL Parlay Picks & Free Predictions

Final Score: LA Rams 26-23
The Pick: LA Rams +115 & Under 52 (-105)
A $100 Parlay Bet will return $320 in Profit

NFL Odds source: Bovada Sportsbook

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