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Chicago (11-4-0) at San Francisco (11-4-0)
- When: Dec 28 2025, 8:20 PM
- Where: Levi’s Stadium, Santa Clara, CA
- Where to watch: NBC/Peacock
- Last Meeting: SF 38-13, December 8th, 2024
Chicago vs San Francisco Preview & Prediction
Spread: San Francisco -3.5
Moneyline: San Francisco (-200)
Total: 52.0
Chicago Bears Betting Overview
Chicago’s rise this season has been loud, fast, and impossible to ignore. In Ben Johnson’s first year running the show, the Bears transformed from an afterthought into a legitimate NFC power. The foundation starts up front. A physical offensive line has unlocked one of the league’s most effective rushing attacks and allowed Caleb Williams to grow without forcing the game onto his shoulders.
Williams has taken the next step when it matters most. Late games have become his playground. Chicago has made a habit of pulling wins out of chaos, trailing late and flipping outcomes with confidence and composure. That mental edge keeps the Bears dangerous even when they fall behind, which is critical against elite opponents.
This game carries massive stakes. Chicago is fighting to lock up the NFC North and remain in the race for the conference top seed. Expect urgency, creativity, and an aggressive mindset. The Bears will not be intimidated by the moment or the venue.
Bears Player Prop Pick: Caleb Williams over 224.5 passing yards – Chicago has shown a willingness to let Williams attack downfield in high leverage games, especially when matchups tighten late.
San Francisco 49ers Betting Overview
San Francisco remains the gold standard for offensive structure. Kyle Shanahan’s system continues to evolve, blending creativity with ruthless efficiency. The emergence of Brock Purdy has allowed the offense to lean into the passing game without losing balance, and the results have been dominant.
The 49ers offense has been operating at a historic level, sustaining drives and finishing possessions with surgical precision. Punts have essentially disappeared from the game plan recently, which speaks volumes about execution and confidence. When San Francisco gets rolling, they squeeze opponents by limiting possessions and controlling tempo.
Defensively, injuries have forced younger players into larger roles, particularly along the defensive front. While the pass rush has not been overwhelming, recent contributions from rookie linemen suggest improvement at the right time. San Francisco does not need defensive fireworks, just timely stops.
With the NFC West title and potential home field advantage on the line, this game has playoff intensity written all over it.
49ers Player Prop Pick: Brock Purdy over 254.5 passing yards – San Francisco’s offense is flowing through Purdy, especially against teams capable of scoring and forcing aggressive play calling.
Betting Outlook & NFL Expert Prediction
This matchup profiles as an offensive showcase. Both teams are efficient, creative, and comfortable playing in high pressure situations. Chicago’s resilience keeps them within striking distance, but San Francisco’s consistency and home edge tilt the outcome.
Expect points, long drives, and a game that stays competitive deep into the fourth quarter.
Chicago covers the spread narrowly, and the total pushes toward the over in a primetime showdown worthy of the stakes.
Final Score: 49ers 30, Bears 27
Lean: Chicago +3.5
Total: Over 52.0
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
