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Cavaliers vs Celtics Odds, Picks & Prediction

Cleveland seeks fourth straight win vs Boston, expert odds, picks, and betting preview

(Photo by Getty Images) Jaylen Brown
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Cleveland (3-1) at Boston (1-3)

  • When: Oct 29 2025, 7:00 PM
  • Where: TD Garden, Boston, MA, USA
  • TV: ESPN

Cleveland vs Boston Preview & Prediction

Spread: Cleveland -4.0
Moneyline: Cleveland (-180)
Total: 233.5

Cleveland Cavaliers Betting Outlook

The Cavaliers roll into Boston riding a three-game win streak and looking every bit like a team hitting its early-season stride. After dropping their opener to New York, Cleveland bounced back with wins over Brooklyn, Milwaukee, and Detroit all powered by the scorching play of Donovan Mitchell. The star guard has been unstoppable, scoring 31 or more points in three of the team’s first four games while carrying the offense through multiple injuries.

Cleveland remains short-handed, with Darius Garland and Max Strus still out recovering from offseason surgeries. Lonzo Ball rested during the team’s back-to-back, while Sam Merrill joined the injury list with a hip issue. Despite those absences, the Cavs have leaned on their defense and rebounding to stay dominant. Evan Mobley and De’Andre Hunter have stepped up on both ends, with Hunter’s defensive effort — including holding Cade Cunningham to 12 points drawing praise from teammates and coaches alike.

With Mitchell’s scoring and a defense that’s beginning to click, Cleveland looks like a team capable of extending its streak even with a depleted roster.

Boston Celtics Betting Outlook

Boston finally snapped its early-season funk with a blowout win over New Orleans, 122-90, after opening the year 0-3. The biggest spark came from new addition Anfernee Simons, who came off the bench to drop 25 points and drain six threes — instantly igniting the Celtics’ stagnant offense. His growing chemistry with Jayson Tatum and Jaylen Brown gives Boston a much-needed scoring punch in its second unit.

Brown, however, continues to manage a lingering hamstring issue, though he still contributed 15 points and seven rebounds in Monday’s win. The Celtics’ defense looked much sharper in that victory, forcing turnovers and moving the ball effectively in transition — a far cry from their sluggish start to the season.

Boston now faces a Cleveland team that’s been red-hot, but this matchup at home offers a chance to build momentum and show they can hang with one of the East’s top squads.

NBA Prediction & Betting Angle

This matchup pits Cleveland’s offensive star power against Boston’s improving defensive effort. The Cavaliers are clicking despite injuries, but Boston’s depth and home-court advantage could even the playing field. Expect a competitive contest with swings on both sides before the hosts pull ahead late.

Final Score:  Celtics 117, Cavaliers 112
Lean:  Boston +155
Total: 
Under 233.5 

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