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Denver (1-1-0) at LA Chargers (2-0-0)
- When: Sep 21 2025, 4:05 PM
- Where: SoFi Stadium, Inglewood, CA
- Where to watch: CBS
- Last Meeting: LAC 34-27, December 19th, 2024
Denver vs LA Chargers Preview & Prediction
Spread: LA Chargers -2.5
Moneyline: LA Chargers (-150)
Total: 46.0
Los Angeles Chargers Betting Outlook
The Chargers (2-0) are rolling and chasing their first 3-0 start since 2002. Justin Herbert has looked sharp, and LA already owns divisional wins over Kansas City in Brazil and the Raiders in Las Vegas. Now, their home opener at SoFi adds extra juice.
Even with Khalil Mack sidelined after an elbow injury, his leadership remains visible on the sidelines, boosting a defense that’s been flying around. Jim Harbaugh has this group motivated and efficient, making the Chargers a dangerous home favorite.
Prediction Angle: If Herbert continues pushing the ball downfield and LA’s pass rush maintains pressure, the Chargers should control the game and cover.
Denver Broncos Betting Outlook
The Broncos (1-1) had a frustrating Week 2, dropping a one-point loss at Indianapolis due to a costly penalty. Now they head to LA seeking redemption. Sean Payton knows divisional battles define seasons, and he’ll have his team ready.
Courtland Sutton points out SoFi often feels like a Broncos home game with Denver fans bringing the noise. That energy could help spark an offense needing a sharper performance in clutch moments.
Still, Denver’s defense must find a way to slow Herbert in a game where one mistake could swing momentum.
Prediction Angle: The Broncos will hang around but may not have enough firepower to match LA’s offensive tempo in crunch time.
NFL Prediction & Betting Angle
Division rivalries are rarely easy, but momentum and home-field edge favor the Chargers. Expect Herbert and company to capitalize late in what should be a competitive matchup.
Final Score: Chargers 27, Broncos 20
Lean: LA Chargers -2.5
Total: Over 46.0
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
