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Rams vs Lions NFL Odds and Score Prediction

Rams vs Lions odds, matchup preview and expert score prediction for Sunday afternoon at SoFi Stadium.

(Photo by Getty Images) Matthew Stafford
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Detroit (8-5-0) at LA Rams (10-3-0)

  • When: Dec 14 2025, 4:25 PM
  • Where: SoFi Stadium, Inglewood, CA
  • Where to watch: FOX
  • Last Meeting: DET 26-20, September 8th, 2024

Detroit vs LA Rams Preview & Prediction

Spread: LA Rams -5.5
Moneyline: LA Rams (-260)
Total: 54.5

Los Angeles Rams Breakdown

Los Angeles enters Sunday as a 5.5 point home favorite with the total sitting at 54.5, and the Rams find themselves thriving years after a quarterback move that once shook the league. What looked brutal at the time has aged well, as the Rams sit at 10-3 and firmly in the NFC title conversation.

Matthew Stafford has turned back the clock, playing at an MVP caliber level while commanding one of the league’s most efficient passing attacks. With elite weapons at his disposal and Sean McVay calling plays with confidence, Los Angeles has scored at least 20 points in 11 of its last 12 games. The offense looks comfortable in shootouts, controlled games, and everything in between.

The Rams also benefit from continuity and health at the right time. Playing at SoFi Stadium gives them speed advantages, spacing advantages, and the ability to dictate tempo. This is not the same Rams team that relied on defensive slugfests. This version wins by overwhelming opponents with execution and balance.

Against a battered Detroit secondary, Los Angeles should be able to stretch the field and capitalize on coverage mismatches. If Stafford has time, this offense can quickly turn this game into a scoreboard race.

Detroit Lions Breakdown

Detroit arrives at 8-5, still dangerous, still explosive, but increasingly thin on defense. Injuries have torn through the Lions’ secondary, forcing them to sign veteran depth just to survive. That reality makes life difficult against an offense as sharp as Los Angeles.

Offensively, the Lions continue to produce at an elite level, leading the league in scoring despite setbacks. Their success is rooted in versatility, creativity, and relentless pace. Detroit is comfortable attacking defenses horizontally and vertically, and they have leaned into adaptability rather than forcing one approach.

The concern for Detroit is not whether they can score, but whether they can get stops. Asking a depleted secondary to hold up for four quarters in Los Angeles is a tall order, especially if the Rams jump out early and force Detroit to abandon balance.

Prediction and Betting Outlook

This game sets up as one of the highest scoring matchups of the week. Both offenses rank among the league’s best, and the Total reflects that expectation. Detroit will trade punches early, but Los Angeles’ healthier roster and home field edge should separate them late.

Final Score: Rams 31, Lions 24
Lean: LA Rams -5.5
Total: 
Over 54.5 

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