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Eagles vs Lions Odds, Expert Preview & Score Pick

Eagles vs Lions betting preview with expert analysis, odds breakdown and a sharp score prediction.

(Photo by Getty Images) A.J. Brown
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Detroit (6-3-0) at Philadelphia (7-2-0)

  • When: Nov 16 2025, 8:20 PM
  • Where: Lincoln Financial Field, Philadelphia, PA
  • Where to watch: Philadelphia, PA
  • Last Meeting: Philadelphia, PA

Detroit vs Philadelphia Preview & Prediction

Spread: Philadelphia -2.5
Moneyline: Philadelphia (-150)
Total: 46.5

Philadelphia Eagles Betting Outlook

Philadelphia enters as a 2.5 point favorite, sitting at 7 2 but far from satisfied with its offensive efficiency. The defense keeps bailing this team out, while the offense continues to sputter. The focal point this week is A.J. Brown’s frustration after a three-target game, and his vocal push for more involvement.

Jalen Hurts and Nick Sirianni insist the chemistry is fine, but the Eagles know they cannot beat top-tier opponents if the passing game remains this clunky. Still, Philly’s home field has been a major advantage, with the Eagles winning 13 of their last 14 in the building. Against one of the league’s highest-scoring offenses, they’ll need clean drives and fewer stalled series to control the pace.

Eagles Player Prop Pick: A.J. Brown Over 67.5 Receiving Yards – Expect intentional involvement early as the Eagles try to get their star back into rhythm.

Detroit Lions Betting Outlook

Detroit arrives at 7 2 with one of the most dangerous offenses in the NFL, averaging over 31 points per game. Jared Goff is performing at an elite level, leading the league in completion percentage and shredding defenses with crisp timing and accuracy. With Dan Campbell calling plays again, the Lions just put up a season-high 546 yards at Washington.

The Lions’ identity is a perfect blend of toughness and explosiveness, and their ball security has been remarkable: 21 passing TDs, 13 rushing scores and only six turnovers all season. They relish road environments like Philadelphia, feeding off energy and hostility rather than shrinking from it. If Goff stays clean and the offense maintains rhythm, Detroit has every tool to punch back.

Lions Player Prop Pick: Jared Goff Over 1.5 Passing Touchdowns – Detroit’s red-zone efficiency and aggressive play-calling set him up well in this matchup.

Expert Betting Outlook & NFL Prediction

Detroit’s offense is humming, but Philadelphia at home is a different animal. Expect a tight, high-pressure game where both passing attacks have moments, but the Eagles’ defense gets just enough stops in the fourth quarter.

Final Score:  Eagles 27, Lions 24
Lean:  Philadelphia -2.5
Total: 
Over 46.5 

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