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Louisville Seeks Follow-up Win vs. Rested Florida State in ACC Showdown

The conference rival Florida State Seminoles and Louisville Cardinals will meet on the field on Friday at Cardinal Stadium in Kentucky.

(Photo by George Walker/Getty Images) Malik Cunningham

NCAAF Matchup: Florida State @ Louisville
When: 7:30 PM ET, Friday, September 16, 2022
Where: Cardinal Stadium, Louisville, Kentucky
Where to watch: ESPN

Florida State @ Louisville
Moneyline

Florida State   -150
Louisville   +130

Florida State @ Louisville
Point Spread

Florida State   -3.0 (-110)
Louisville   3.0 (-110)

Florida State @ Louisville
Total

Over   57.0 (-110)
Under   57.0 (-110)

Passing Team Leaders:
Florida State: Jordan Travis 467 Yds
Louisville : Malik Cunningham 347 Yds

by FLM

The Florida State Seminoles are one win away from their best start since 2015.

OK, that’s just three wins, but they will try to make it happen Friday night when they travel to Louisville, Ky., to face the Cardinals. It’s the Atlantic Coast Conference opener for Florida State; Louisville already has one conference loss.

The Seminoles (2-0, 0-0 ACC) are coming off a bye week, which followed one of their biggest wins in recent memory when they beat LSU, 24-23, in New Orleans on Sept. 4. That, on the heels of a 47-7 rout of Duquesne, gave Florida State back-to-back victories to open a season for the first time in coach Mike Norvell’s three seasons in Tallahassee.

2025 Super Bowl LIX Odds

Betting Odds Trends

Louisville Cardinals
Louisville is 2-4 ATS in its last 6 games at home
Louisville is 14-7 SU in its last 21 games at home
Louisville is 2-4 SU in its last 6 games at home
The total has gone OVER in 11 of Louisville’s last 16 games at home
Louisville is 5-1 ATS in its last 6 games when playing Florida State
Louisville is 4-2 SU in its last 6 games when playing Florida State
The total has gone OVER in 6 of Louisville’s last 8 games when playing Florida State
Louisville is 4-1 ATS in its last 5 games when playing at home against Florida State
The total has gone OVER in 4 of Louisville’s last 5 games when playing at home against Florida State
Florida State Seminoles
Florida State is 4-1 ATS in its last 5 games
Florida State is 4-1 SU in its last 5 games
The total has gone UNDER in 5 of Florida State’s last 5 games
Florida State is 4-1 ATS in its last 5 games on the road
Florida State is 8-16-1 ATS in its last 25 games on the road
Florida State is 4-15 SU in its last 19 games on the road
The total has gone UNDER in 6 of Florida State’s last 7 games on the road
Florida State is 1-5 ATS in its last 6 games when playing Louisville
Florida State is 2-4 SU in its last 6 games when playing Louisville
The total has gone OVER in 6 of Florida State’s last 8 games when playing Louisville
Florida State is 1-4 ATS in its last 5 games when playing on the road against Louisville
The total has gone OVER in 4 of Florida State’s last 5 games when playing on the road against Louisville

College Football Parlay Picks & Free Predictions

Final Score: Florida State 27-20
The Pick: Florida State -3 & Under 57
A $100 Parlay Bet will return $264 in Profit

NCAAF Odds source: Bovada Sportsbook

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