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Indiana (5-0) at Oregon (5-0)
- When: Oct 11 2025, 3:30 PM
- Where: Autzen Stadium, Eugene, OR
- Where to watch: CBS
(7) Indiana vs (3) Oregon Preview & Prediction
Spread: Oregon -7.0
Moneyline: Oregon (-290)
Total: 53.0
Oregon Ducks Betting Outlook
The No. 3 Oregon Ducks return home looking every bit like a playoff contender after their thrilling double-overtime road win over Penn State. Rested from a bye week, Oregon now steps into another heavyweight Big Ten clash against undefeated No. 7 Indiana at Autzen Stadium.
The Ducks’ dominance at home has been unmatched, they’ve won 18 straight in Eugene and carry a 23-game regular season winning streak overall. Offensively, Oregon has been unstoppable in the red zone, scoring on all 23 trips inside the 20-yard line. Quarterback Dante Moore continues to play with confidence, managing the game efficiently while allowing the Ducks’ running game and defense to set the tone.
Defensively, Oregon has been elite. The Ducks rank third in the nation in pass defense, allowing just 123.4 yards per game through the air. They’ve also surrendered only two passing touchdowns all season, with their secondary sealing the Penn State win in double overtime with a key interception. Head coach Dan Lanning praised his team’s adaptability and discipline, emphasizing their ability to adjust coverage schemes week to week.
Prediction for Oregon: Expect the Ducks’ defensive front to make the difference again. If Moore stays composed and Oregon controls the clock, the Ducks are well-positioned to stay unbeaten and cover the spread at home.
Indiana Hoosiers Betting Outlook
The No. 7 Indiana Hoosiers are no longer underdogs, they’ve earned their way into national relevance with another perfect 5-0 start. But now comes their biggest test of the season: a road trip to Eugene to face one of the most complete teams in the country.
Quarterback Fernando Mendoza, a Cal transfer, has been lights out. He’s completed over 72% of his passes for 1,208 yards, 16 touchdowns, and just one interception. Mendoza’s poise under pressure has transformed the Hoosiers into a legitimate Big Ten threat. Indiana’s offense balances that air attack with a powerful run game that’s churned out 1,339 yards and 11 rushing scores through five games.
On the defensive side, Indiana has been a brick wall, holding opponents to just 9.6 points per game — third-best in the nation. Their ability to force turnovers and limit explosive plays has been key to their early success. Head coach Curt Cignetti insists his squad will stick to their formula: play physical, stay composed, and force Oregon to earn every yard.
Prediction for Indiana: The Hoosiers have the defense to hang around, but containing Oregon at Autzen is a tall order. If Mendoza keeps the offense balanced, they could make this one interesting deep into the fourth quarter.
Final Score Prediction
The Ducks’ depth, defense, and home-field edge prove too much as they grind out another statement win to remain unbeaten.
Final Score: Oregon 33, Indiana 23
Lean: Oregon -7.0
Total: Over 53.0
- NCAA Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
