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Indianapolis (8-2-0) at Kansas City (5-5-0)
- When: Nov 23 2025, 1:00 PM
- Where: GEHA Field at Arrowhead Stadium, Kansas City, MO
- Where to watch: CBS
- Last Meeting: IND 20-17, September 25th, 2022
Indianapolis vs Kansas City Preview & Prediction
Spread: Kansas City -3.5
Moneyline: Kansas City (-195)
Total: 50.0
Indianapolis Colts Betting Preview
Indianapolis walks into Week 12 sitting atop the AFC South, which absolutely no one had penciled in back in September. But here they are at 5 wins in their last 6, coming off a bye week and riding a hot streak led by Daniel Jones playing like he discovered a cheat code, and Jonathan Taylor stomping through defenses like he is allergic to being tackled.
The Colts have been winning with physicality, creativity on offense and enough timely defense to frustrate better rosters. More importantly, the extra week of prep gives Shane Steichen added time to cook something up for a Chiefs team that is playing far below its usual standard.
Indianapolis has been consistent with its ground-and-pound mentality, eating up clock, protecting leads and hitting defenses in the mouth. Against a Kansas City unit that has been gift-wrapping penalties and turnovers, the Colts’ formula travels well.
Kansas City Chiefs Betting Preview
Kansas City is in a spot nobody expected: tied in knots, trailing Denver in the division and barely clinging to AFC playoff positioning. The mistakes keep piling up. Penalties. Turnovers. Defensive breakdowns. Another week, another chance for Patrick Mahomes to drag the roster back to normal.
Last week’s loss to Denver felt like a summary of their entire season: big drives stalling at the worst possible moments, a run game that ghosts the offense, and costly late mistakes that wipe out strong stretches.
Andy Reid openly admitted the urgency is rising. They need balance, discipline and actual execution rather than “Mahomes, please save us again.”
Arrowhead should help — but the Chiefs have not played there in almost a month and will not return again until December 7. Their offensive line remains banged up and Travis Kelce is battling extra defensive attention in every matchup.
Still, Kansas City is dangerous, desperate and fully aware this game matters.
NFL Prediction & Betting Angle
Kansas City is the more talented team, but Indianapolis is the one playing cleaner football, running better, and entering the matchup with rest, momentum and confidence. The Colts’ balance gives them the edge early, but Mahomes keeps it from slipping into disaster territory.
Final Score: Colts 27, Chiefs 24
Lean: Indianapolis (+165)
Total: Over 50.0
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
