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Indianapolis (5-1-0) at LA Chargers (4-2-0)
- When: Oct 19 2025, 4:05 PM
- Where: SoFi Stadium, Inglewood, CA
- Where to watch: CBS
- Last Meeting: LAC 20-3, December 26th, 2022
Indianapolis vs LA Chargers Preview & Prediction
Spread: LA Chargers -2.0
Moneyline: LA Chargers (-133)
Total: 48.5
Indianapolis Colts: Steichen Returns to Familiar Ground
Shane Steichen is making a homecoming, only this time, he’s walking into SoFi Stadium as the head coach of the hottest offense in football. The Colts (5-1) are lighting up scoreboards under Steichen’s direction, averaging over 30 points per game and playing like a team with something to prove.
For Steichen, this matchup is personal. He spent nine years with the Chargers organization from his early days breaking down film in San Diego to calling plays in Los Angeles. Now, he gets a chance to show his old team how far he’s come.
Quarterback Daniel Jones has been reborn under Steichen’s system, blending aggressive downfield passing with smart, efficient reads. The Colts’ attack starts with Jonathan Taylor, who’s leading the league in rushing and playing with the kind of physical dominance that makes opposing defenses flinch. His improved blocking has also given Jones extra time to cook in the pocket.
Expect Steichen to stay aggressive against a Chargers defense that’s been leaking yards on the ground. With Khalil Mack only recently returning from injury, Indianapolis might look to pound the ball early and set up play action late.
Colts Prediction: Indianapolis keeps it tight but falls short in a late drive.
Player Prop Pick: Jonathan Taylor Over 89.5 Rushing Yards
Los Angeles Chargers: Harbaugh’s Crew Looking to Regain Control
The Chargers (4-2) may be favored, but they know better than to underestimate Steichen’s offense. Head coach Jim Harbaugh has praised his former colleague all week, though don’t expect sentimentality once the whistle blows. Los Angeles is coming off a physical road stretch and needs to tighten up defensively after allowing 20+ points in four straight games.
The return of Khalil Mack could be massive. His presence on the edge brings the kind of chaos that forces turnovers and disrupts rhythm, exactly what the Chargers need against a Colts team that thrives on balance.
On offense, Justin Herbert continues to look more comfortable with every week, and this game gives him a chance to remind everyone why he’s one of the NFL’s elite. He’s been spreading the ball around efficiently, but with Steichen’s history in L.A., expect Herbert to target deep routes early to exploit mismatches.
Chargers Prediction: Herbert leads a second-half surge to secure the win.
Player Prop Pick: Justin Herbert Over 1.5 Passing Touchdowns
Expert Betting Outlook & NFL Prediction
Steichen’s return to Los Angeles turns into a chess match with fireworks, but Herbert’s home-field confidence and a healthier defense help the Chargers squeak out a close win in a thriller that goes down to the wire.
Final Score: Chargers 27, Colts 24
Lean: LA Chargers -2.0
Total: Over 48.5
- NFL Football Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
