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Indianapolis (2-0-0) at Tennessee (0-2-0)
- When: Sep 21 2025, 1:00 PM
- Where: Nissan Stadium, Nashville, TN
- Where to watch: CBS
- Last Meeting: IND 38-30, December 22nd, 2024
Indianapolis vs Tennessee Preview & Prediction
Spread: Indianapolis -5.0
Moneyline: Indianapolis (-235)
Total: 43.5
Tennessee Titans: Searching for Stability
The Titans are still trying to shake off their extended losing streak. At 0-2 this season and losers of eight straight overall, they’ve yet to find the spark under rookie QB Cam Ward. The rookie has shown flashes, but 11 sacks already highlight how shaky the offensive line has been.
Divisional play adds even more urgency, and Tennessee knows a win here keeps them alive in the AFC South picture. Jonathan Taylor torched them last December, which only makes their job tougher this time around. If Ward can get the ball out quicker and the defense can limit explosive plays, the Titans at least have a puncher’s chance.
Indianapolis Colts: A Hot Start
The Colts are sitting pretty at 2-0 and looking like an AFC South frontrunner. Daniel Jones has been sharp, completing over 71% of his passes while leading Indy to scores on nearly every drive. Add in Jonathan Taylor’s league-leading rushing numbers and an opportunistic defense led by new safety Cam Bynum, and Indianapolis has the balance needed to sustain its momentum.
The Colts also bring in the league’s best turnover margin (+4), showing they don’t beat themselves. At home, that discipline makes them even more dangerous.
Prediction & Betting Angle
The Colts’ offensive balance, combined with Tennessee’s inability to protect Ward, makes this matchup lean Indianapolis. With Taylor thriving on the ground and Jones keeping drives alive, Indy should dictate the pace.
Final Score: Colts 27, Titans 17
Lean: Indianapolis -5.0
Total: Over 43.5
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
