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Jacksonville (2-1-0) at San Francisco (3-0-0)
- When: Sep 28 2025, 4:05 PM
- Where: Levi’s Stadium, Santa Clara, CA
- Where to watch: FOX
Game Odds, Spread, Moneyline & Total
Jacksonville Jaguars @ San Francisco 49ers
Moneyline
Jacksonville Jaguars +155
San Francisco 49ers -180
Jacksonville Jaguars @ San Francisco 49ers
Point Spread
Jacksonville Jaguars 3.0 (EVEN)
San Francisco 49ers -3.0 (-120)
Jacksonville Jaguars @ San Francisco 49ers
Total
Over 46.5 (-105)
Under 46.5 (-115)
- Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
Trevor Lawrence NFL Preview & Props
Trevor Lawrence heads into Week 4 locked in as the Jaguars prepare for a huge clash with the San Francisco 49ers. His ability to extend plays and push the ball downfield has been a cornerstone for Jacksonville’s offense, and all eyes will be on how he handles one of the league’s toughest defenses.
Jacksonville Jaguars @ San Francisco 49ers
Anytime Touchdown Scorer
Trevor Lawrence (JAX) +525
Jacksonville Jaguars @ San Francisco 49ers
Who will Score 2 or more Touchdowns?
Trevor Lawrence (JAX) +4500
Jacksonville Jaguars @ San Francisco 49ers
To Score 3 or more Touchdowns
Trevor Lawrence (JAX) +12500
Jacksonville Jaguars @ San Francisco 49ers
Total Passing Touchdowns – Trevor Lawrence (JAX)
Over 1.5 (+120)
Under 1.5 (-160)
Jacksonville Jaguars @ San Francisco 49ers
Alternate Passing Touchdowns – Trevor Lawrence (JAX)
To Record 1+ Passing Touchdowns -450
To Record 2+ Passing Touchdowns +115
To Record 3+ Passing Touchdowns +400
To Record 4+ Passing Touchdowns +1200
Jacksonville Jaguars @ San Francisco 49ers
Total Passing Attempts – Trevor Lawrence (JAX)
Over 32.5 (-145)
Under 32.5 (+110)
Jacksonville Jaguars @ San Francisco 49ers
Total Completions – Trevor Lawrence (JAX)
Over 20.5 (-115)
Under 20.5 (-115)
Jacksonville Jaguars @ San Francisco 49ers
Longest Pass Completion – Trevor Lawrence (JAX)
Over 35.5 (-110)
Under 35.5 (-120)
Jacksonville Jaguars @ San Francisco 49ers
Total Interceptions Thrown – Trevor Lawrence (JAX)
Over 0.5 (-150)
Under 0.5 (+115)
Jacksonville Jaguars @ San Francisco 49ers
Total Passing Yards – Trevor Lawrence (JAX)
Over 230.5 (-115)
Under 230.5 (-115)
Jacksonville Jaguars @ San Francisco 49ers
Alternate Passing Yards – Trevor Lawrence (JAX)
To Record 150+ Passing Yards -900
To Record 175+ Passing Yards -450
To Record 200+ Passing Yards -225
To Record 225+ Passing Yards -120
To Record 250+ Passing Yards +155
To Record 275+ Passing Yards +275
To Record 300+ Passing Yards +475
To Record 325+ Passing Yards +330
To Record 350+ Passing Yards +1200
Jacksonville Jaguars @ San Francisco 49ers
Who will have more Passing Yards in the game?
Brock Purdy (SF) -160
Trevor Lawrence (JAX) +120
Jacksonville Jaguars @ San Francisco 49ers
Longest Rushing Attempt – Trevor Lawrence (JAX)
Over 7.5 (-110)
Under 7.5 (-120)
Jacksonville Jaguars @ San Francisco 49ers
Total Rushing Yards – Trevor Lawrence (JAX)
Over 11.5 (-115)
Under 11.5 (-115)
Jacksonville Jaguars @ San Francisco 49ers
Alternate Rushing Yards – Trevor Lawrence (JAX)
To Record 10+ Rushing Yards -135
To Record 15+ Rushing Yards +150
To Record 20+ Rushing Yards +260
To Record 25+ Rushing Yards +400
Jacksonville Jaguars @ San Francisco 49ers
Total Passing and Rushing Yards – Trevor Lawrence (JAX)
Over 240.5 (-115)
Under 240.5 (-115)
Trevor Lawrence Statistics
| Game | P. TDs | P. Yards | INT | Comp% | Rating |
| 3 | 4 | 671 | 4 | 55.8 | 70.3 |
Trevor Lawrence Past Results
| Passing | ||||||||
| W | vs | Score | Yds | CMP | ATT | Y/A | LNG | TD/Int |
| 3 | W
|
222 | 20 | 40 | 5.5 | 46 | 0/1 | |
| 2 | @
|
L
|
271 | 24 | 42 | 6.5 | 40 | 3/2 |
| 1 | W
|
178 | 19 | 31 | 5.7 | 24 | 1/1 | |
| Russhing | ||||||
| W | Att | YDS | AVG | LNG | TD | FL |
|---|---|---|---|---|---|---|
| 3 | 2 | 9 | 4.5 | 10 | 0 | 0 |
| 2 | 2 | 4 | 2.0 | 3 | 0 | 0 |
| 1 | 4 | 12 | 3.0 | 10 | 0 | 0 |
NFL Player Props Picks & Predictions
Trevor Lawrence has the arm strength and weapons to stretch defenses, and San Francisco’s secondary has surrendered multiple explosive plays this season. With Calvin Ridley and Christian Kirk thriving downfield, Lawrence has every opportunity to connect on a long strike.
Trevor Lawrence Props Pick: Longest Pass Completion –
Over 35.5 (-110)
A $110 Bet on that Props will return $210
- NFL Props source: Bovada Sportsbook
