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Jaguars vs Broncos Odds Preview and Score Prediction

Broncos vs Jaguars betting preview with spread, total, odds breakdown, and final score prediction.

(Photo by Getty Images) Bo Nix
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Jacksonville (10-4-0) at Denver (12-2-0)

  • When: Dec 21 2025, 4:05 PM
  • Where: Empower Field at Mile High, Denver, CO
  • Where to watch: FOX
  • Last Meeting: DEN 21-17, October 30th, 2022

Jacksonville vs Denver Preview & Prediction

Spread: Denver -3.5
Moneyline: Denver (-175)
Total: 47.0

Denver Broncos Betting Breakdown

Denver has become the center of the sports universe, and the Broncos are a big reason why. While the Nuggets and Avalanche continue their championship-level runs, the Broncos have quietly put together an NFL-best 12-2 record and are positioning themselves for something much bigger than just a playoff spot.

This team believes it is their turn. Veterans in the locker room have embraced the city’s winning culture, and the message has been consistent all week. Denver is not satisfied yet. Despite already locking up a postseason berth, the Broncos are chasing the top seed in the AFC and the valuable first-round bye that comes with it.

Bo Nix has taken a massive leap in his second season, developing into one of the league’s most reliable quarterbacks. He has been especially dangerous late, helping Denver rack up comeback wins and dominate close games. Pair that with a relentless defense that leads the league in sacks, and you have a team built to win tight, physical matchups.

The Broncos have been lethal in the fourth quarter, particularly at home. Opponents consistently fade late at altitude, and Denver has taken full advantage. That trend matters against a Jacksonville team that has been red-hot offensively but now faces one of the toughest environments in the league.

Denver is favored by 3.5, and the confidence level inside the building suggests they are treating this like a playoff game rather than a tune-up.

Jacksonville Jaguars Betting Breakdown

Jacksonville arrives in Denver playing its best football of the season. Winners of five straight, the Jaguars have turned into an offensive juggernaut since their bye week, piling up points and overwhelming opponents on both sides of the ball.

Trevor Lawrence is operating at a different level right now. He looks fully comfortable in the system and has built immediate chemistry with new weapons, helping Jacksonville average nearly 33 points per game during its winning streak. The Jaguars have been explosive early and ruthless when given short fields.

Defensively, Jacksonville has thrived by forcing turnovers. Their ability to generate interceptions and swing momentum has been a major reason for their surge. Still, this matchup presents a different challenge. Denver does not beat itself often, especially at home, and that limits Jacksonville’s usual advantages.

The Jaguars are also chasing history. They have already knocked off every AFC West opponent once this season and now have a chance to complete a rare division sweep. That motivation is real, but so is the difficulty of doing it in Denver against a team that finishes games better than anyone in football.

Betting Outlook and Prediction

Denver is laying 3.5 points at home with the total set at 47.0. Jacksonville’s offense is good enough to trade scores early, but Denver’s defense, home-field edge, and fourth-quarter dominance give the Broncos a clear advantage as the game wears on.

This feels like a playoff-style matchup where execution late decides everything. Denver has been the more trustworthy team in those moments all season.

Final Score: Broncos 27, Jaguars 24
Lean: Jacksonville +3.5
Total: 
Over 47.0 

2026 CFP National Championship

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