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Jacksonville (11-4-0) at Indianapolis (8-7-0)
- When: Dec 28 2025, 1:00 PM
- Where: Lucas Oil Stadium, Indianapolis, IN
- Where to watch: FOX
- Last Meeting: JAX 36-19, December 7th, 2025
Jacksonville vs Indianapolis Preview & Prediction
Spread: Jacksonville -6.0
Moneyline: Jacksonville (-275)
Total: 48.5
Jacksonville Jaguars Betting Breakdown
Jacksonville’s rise this season has been anything but accidental. From the first weeks of training camp, the tone was physical, demanding, and fast paced, and that identity has carried straight into December. Now the Jaguars arrive in Week 17 riding a six game winning streak, sitting atop the AFC South, and staring at a legitimate chance to secure both the division and prime playoff positioning.
This team has handled adversity well. Even after losing a major cornerstone to a season ending injury, Jacksonville never flinched. Trevor Lawrence continues to play confident, controlled football, delivering efficient performances while limiting mistakes. Over the past few weeks, the offense has consistently finished drives, and that balance has made the Jaguars difficult to slow down.
The motivation is clear. A win here would complete a season sweep over Indianapolis and push Jacksonville closer to a rare 12 win season. At home, with postseason stakes attached, the Jaguars are fully locked in. The only concern comes defensively, where injuries have thinned the secondary, forcing younger players into bigger roles. Still, Jacksonville’s pass rush and ball control offense help protect those weaknesses.
Indianapolis Colts Betting Breakdown
Indianapolis enters this matchup heading in the opposite direction. What once looked like a division runaway has unraveled quickly, with five straight losses and mounting pressure on a roster that suddenly looks patched together. Injuries have hit the Colts at the worst possible time, especially at quarterback and in the secondary.
Philip Rivers has stepped in admirably under impossible circumstances, but the offense lacks explosiveness and margin for error. Sustaining drives has been a challenge, and turnovers have consistently flipped momentum. Defensively, coverage breakdowns and missed assignments have turned manageable games into uphill battles.
While the Colts still technically remain alive, urgency alone does not fix structural issues. Facing a Jacksonville team playing its best football of the season puts Indianapolis in a tough spot, especially on the road.
Betting Outlook and Final Prediction
The Jaguars have momentum, clarity, and playoff motivation, while Indianapolis is simply trying to survive. Jacksonville’s offense should control tempo, and even with defensive injuries, the Colts may struggle to keep pace.
Jacksonville covers the spread, and the game leans toward the over as the Jaguars continue their push toward a division title.
Final Score: Jaguars 31, Colts 20
Lean: Jacksonville -6.0
Total: Over 48.5
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
