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The division rival Los Angeles Chargers and Kansas City Chiefs are set to renew hostilities on Thursday when they meet at GEHA Field at Arrowhead Stadium.

Featured Image Caption (Photo by Norm Hall/Getty Images) Patrick Mahomes

NFL Matchup: Los Angeles Chargers @ Kansas City Chiefs
When: 8:15 PM ET, Thursday, September 15, 2022
Where: GEHA Field at Arrowhead Stadium, Kansas City, Missouri
Where to watch: Prime Video

Los Angeles Chargers @ Kansas City Chiefs
Point Spread

Los Angeles Chargers   4.0 (-110)
Kansas City Chiefs   -4.0 (-110)

Los Angeles Chargers @ Kansas City Chiefs
Total

Over   54.0 (-110)
Under   54.0 (-110)

Los Angeles Chargers @ Kansas City Chiefs
Moneyline

Los Angeles Chargers   +175
Kansas City Chiefs   -210

Passing Team Leaders:
Los Angeles Chargers: Justin Herbert 279 Yds
Kansas City Chiefs: Patrick Mahomes 360 Yds

by FLM

The narrative that the Kansas City Chiefs might have diminished firepower after the offseason departure of Tyreek Hill was quelled when quarterback Patrick Mahomes threw five touchdown passes in the club’s season-opening win over the Arizona Cardinals.

The Chiefs will aim to follow up the strong performance when they host their AFC West rival, the Los Angeles Chargers, on Thursday night.

Kansas City (1-0) totaled 488 offensive yards and 33 first downs in the 44-21 road win over Arizona. And the offseason trade of the speedy Hill to the Miami Dolphins was a non-factor as Mahomes passed for 360 yards and became the sixth player in NFL history to throw five touchdowns on six or more occasions.

2025 Super Bowl LIX Odds

Betting Odds Trends

Kansas City Chiefs
Kansas City is 9-3 ATS in its last 12 games
Kansas City is 12-2 SU in its last 14 games
The total has gone OVER in 8 of Kansas City’s last 9 games
Kansas City is 6-1 ATS in its last 7 games at home
Kansas City is 8-1 SU in its last 9 games at home
The total has gone OVER in 4 of Kansas City’s last 5 games at home
Kansas City is 13-3 SU in its last 16 games when playing LA Chargers
Kansas City is 2-5 ATS in its last 7 games when playing at home against LA Chargers
The total has gone OVER in 4 of Kansas City’s last 6 games when playing at home against LA Chargers
Los Angeles Chargers
The total has gone OVER in 6 of LA Chargers’s last 7 games
LA Chargers is 2-4 ATS in its last 6 games on the road
LA Chargers is 2-4 SU in its last 6 games on the road
The total has gone OVER in 4 of LA Chargers’s last 5 games on the road
LA Chargers is 3-13 SU in its last 16 games when playing Kansas City
LA Chargers is 5-2 ATS in its last 7 games when playing on the road against Kansas City
The total has gone OVER in 4 of LA Chargers’s last 6 games when playing on the road against Kansas City

NFL Parlay Picks & Free Predictions

Final Score: Kansas City 34-23
The Pick: Kansas City -4 & Over 54
A $100 Parlay Bet will return $264 in Profit

NFL Odds source: Bovada Sportsbook

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