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LA Rams (6-2-0) at San Francisco (6-3-0)
- When: Nov 9 2025, 4:25 PM
- Where: Levi’s Stadium, Santa Clara, CA
- Where to watch: FOX
- Last Meeting: SF 26-23, October 2nd, 2025
LA Rams vs San Francisco Preview & Prediction
Spread: LA Rams -6.0
Moneyline: LA Rams (-245)
Total: 49.5
Los Angeles Rams Betting Outlook
The Rams are rolling into Levi’s Stadium looking like they just drank a triple espresso. They’ve won three straight and have given up a grand total of 20 points in that stretch. That’s not defense, that’s stinginess on a biblical level. Matthew Stafford, meanwhile, is in “I still got it” mode. The man’s throwing lasers like he’s auditioning for a Marvel movie. Over his past five games, he’s tossed 16 touchdowns and zero picks, which is basically the quarterback version of eating hot wings in a white shirt and not spilling anything.
Stafford’s main weapon, Davante Adams, is out there reminding everyone why corners have nightmares. He’s been torching defenses and probably ruining at least a few fantasy matchups along the way. But let’s not forget the Rams’ secret weakness: their kickers. Between missed field goals, blocked kicks, and whatever chaos Joshua Karty was doing, it’s been a special teams circus. So much so that they brought in new blood this week, Harrison Mevis and long snapper Jake McQuaide to stop the bleeding. If the Rams can hit their kicks and Stafford stays red-hot, they could avenge that overtime loss earlier this season.
San Francisco 49ers Betting Outlook
On the other sideline, the 49ers are duct-taped together and still dangerous. Injuries have hit them like a meteor shower, Mykel Williams, Fred Warner, Nick Bosa, you name it, but they just keep rolling. Star tight end George Kittle basically told the offense to start dropping 30 a night, and Christian McCaffrey upped the ante to 40 or 50. It’s the football version of a sibling flex-off.
Enter Mac Jones, the redemption arc nobody saw coming. The former New England misfit is suddenly playing the best football of his life in San Francisco. With Brock Purdy’s toe on vacation, Jones has gone 5-2 as a starter, including torching the Rams earlier in the season on one leg and without half his receiving corps. The man might not be pretty doing it, but he’s efficient, kind of like a used Honda that refuses to die.
Special teams? Oh, they finally got that sorted too. After last year’s disasters, Eddy Pineiro hasn’t missed a kick since arriving in Week 2, and Brian Robinson keeps giving them primo field position like it’s his side hustle. If Shanahan can keep that unit from self-destructing, San Francisco’s got a puncher’s chance in this rematch.
NFL Final Score Prediction
Both teams can light up the scoreboard, but the Rams’ defense is playing like they’re allergic to touchdowns. Stafford’s in rhythm, and Los Angeles looks more balanced heading into this one. San Francisco’s injuries and kicking luck might finally catch up to them, even at home.
Final Score: Rams 32, 49ers 24
Lean: LA Rams -6.0
Total: Over 49.5
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
