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No. 15 Michigan vs No. 18 Oklahoma Odds, Preview & Expert Prediction

Michigan and Oklahoma will both be gunning for a victory when they meet at Gaylord Family Oklahoma Memorial Stadium.

(Photo by Getty Images) John Mateer
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Michigan (1-0) at Oklahoma (1-0)

  • When: Sep 6 2025, 7:30 PM
  • Where: Gaylord Family Oklahoma Memorial Stadium, Norman, OK
  • Where to watch: ABC

(15) Michigan vs (18) Oklahoma Preview & Prediction

Spread: Oklahoma -5.0
Moneyline: Oklahoma -204
Total: 44.0

Michigan Wolverines

Michigan enters this showdown with Oklahoma fresh off a 34-17 win over New Mexico. Running back Justice Haynes carried the offense, racking up 159 yards and three touchdowns. His physicality and consistency will be a major factor against a tougher Sooners defense.

The bigger question: how will freshman quarterback Bryce Underwood respond to his first hostile road start? Michigan is prepping him for the noise and chaos, but the atmosphere in Norman is a different beast entirely. Missing linebacker Jaishawn Barham for the first half (due to a targeting suspension) doesn’t help their defense either.

Player Prop to Watch (Michigan): Justice Haynes – Anytime Touchdown Scorer
Haynes looked unstoppable last week, and Michigan will lean on him again to establish the ground game.

Oklahoma Sooners

Oklahoma looked sharp in their 35-3 victory over Illinois State, and the offense clicked behind quarterback John Mateer, who threw for 393 yards and three touchdowns. That passing confidence will be tested by a much stronger Michigan secondary.

The Sooners also hope to get more out of running back Jaydn Ott, a Cal transfer limited in Week 1. Head coach Brent Venables praised his potential, hinting that Ott’s role could expand in this matchup. The offensive line health is also a storyline, with two key starters expected back.

Player Prop to Watch (Oklahoma): John Mateer – Over 1.5 Passing Touchdowns
Mateer’s chemistry with Arbuckle’s scheme makes this prop appealing, especially at home.

Betting Outlook & Prediction

Oklahoma is favored by 5 points with a total set at 44. MyBookie clearly expect a tight defensive game with just enough big plays sprinkled in. Michigan’s offense will try to ground-and-pound through Haynes, while Oklahoma wants Mateer to air it out early and test the Wolverines’ secondary. Expect the Sooners to edge out a physical, grind-it-out clash at home.

Final Score: Oklahoma 23, Michigan 20
Lean: Michigan +5
Total: 
Under 44.0 

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