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Chargers vs Vikings Prediction, Odds & Expert Betting Picks

Expert picks and betting analysis for Chargers vs Vikings. Odds, trends, and score prediction for Thursday night.

(Photo by Getty Images) Justin Herbert
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Minnesota (3-3-0) at LA Chargers (4-3-0)

  • When: Oct 23 2025, 8:15 PM
  • Where: SoFi Stadium, Inglewood, CA
  • Where to watch: Amazon Prime Video
  • Last Meeting: LAC 28-24, September 24th, 2023

Minnesota vs LA Chargers Preview & Prediction

Spread: LA Chargers -3.5
Moneyline: LA Chargers (-192)
Total: 44.5

Los Angeles Chargers Outlook

The Chargers head into Thursday night football looking for a bounce-back performance after dropping three of their last four. Their offense, while potent on paper, has been inconsistent due to injuries up front. Star quarterback Justin Herbert has spent more time dodging defenders than dissecting them, with both tackles Joe Alt and Trey Pipkins listed as game-time decisions. If either returns, expect a noticeable boost in pass protection and run-blocking efficiency.

Jim Harbaugh’s squad has struggled defensively too, surrendering over 30 points in three straight outings and failing to record a takeaway in four games. Coordinator Jesse Minter is looking for any spark to get this group back in sync. Veteran edge rusher Khalil Mack returned last week and made an immediate impact with a sack, though his snap count remains limited.

The bright spot remains Herbert’s connection with his wideouts, especially Keenan Allen, who continues to serve as the offense’s most reliable weapon. If the Chargers can keep Herbert upright and reestablish the run game, they’ll have the edge on a short week against a shaky Minnesota secondary.

Player Prop Pick – Justin Herbert Over 1.5 Passing Touchdowns – Herbert remains a volume passer, and Minnesota’s defense just allowed a perfect passer rating to Jalen Hurts. Expect Herbert to take full advantage.

Minnesota Vikings Outlook

Minnesota’s 3-3 record says “average,” but it feels worse given their preseason expectations. Quarterback Carson Wentz continues to battle through shoulder soreness, yet he’s shown flashes, like his 313-yard outing last week, even while tossing two costly interceptions. With J.J. McCarthy still sidelined, Wentz will once again lead the offense as he looks to stabilize a unit still searching for rhythm.

The Vikings’ biggest issue remains consistency on both sides of the ball. Defensively, Brian Flores’ group has struggled to create turnovers and prevent explosive plays. Offensively, the team lacks a steady field general, that calming, consistent presence who can orchestrate drives and control tempo. Until Wentz or McCarthy establishes that leadership, the Vikings’ offense will continue to have an identity crisis.

Still, there are positives. Receiver Jordan Addison has emerged as Wentz’s favorite target, benefiting from the attention defenses give Justin Jefferson. Addison’s route running and chemistry with Wentz have been impressive, giving Minnesota a reliable spark in an otherwise uneven passing game.

Player Prop Pick – Jordan Addison Over 54.5 Receiving Yards – Addison’s chemistry with Wentz is undeniable, and he’s seen 26 targets over his last three games. Expect volume again in a potential shootout.

Expert Betting Outlook & NFL Prediction

Both teams are banged up, desperate, and short on rest, a perfect recipe for chaos. The Chargers’ offensive talent and Herbert’s poise give them the upper hand, especially if their line holds up. Minnesota’s defense can’t be trusted to contain big plays.

Final Score:  Chargers 27, Vikings 21
Lean:  LA Chargers -3.5
Total: 
Over 44.5 

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