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Wolves vs Knicks NBA Prediction, Odds & Betting Picks

Knicks continue homestand hosting the Timberwolves in a high-energy showdown between two playoff contenders.

(Photo by Getty Images) Karl-Anthony Towns
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Minnesota (4-3) at New York (4-3)

  • When: Nov 5 2025, 7:30 PM
  • Where: Madison Square Garden, New York, NY, USA
  • TV: ESPN

Minnesota vs New York Preview & Prediction

Spread: New York -4.5
Moneyline: New York (-180)
Total: 229.0

New York Knicks Betting Outlook

The Knicks continue their long homestand on Wednesday, looking to keep building momentum after a convincing 119-102 win over the Wizards. Karl-Anthony Towns was unstoppable in that one, dropping a season-high 33 points with 13 rebounds, showcasing exactly why the blockbuster trade with Minnesota has worked out beautifully for both sides.

Towns has fit into New York’s system like a glove, thriving under head coach Mike Brown’s inside-out philosophy. His size, shooting range, and growing confidence are turning the Knicks’ offense into a nightmare matchup. Brown praised his big man’s energy and two-way dominance, saying Towns is “finding his rhythm” as the centerpiece of their attack.

New York’s offense has been balanced and efficient, and while they’re still managing Mitchell Robinson’s minutes after ankle surgeries, the frontcourt remains a force. The Knicks’ ability to dominate the paint while spacing the floor around Towns makes them a tough team to handle at home, especially against a Minnesota squad that’s still adjusting its rotations.

Minnesota Timberwolves Betting Outlook

The Timberwolves arrive in New York riding high after their own strong showing Monday, a 125-109 road win over the Nets. Julius Randle and Donte DiVincenzo, the key pieces traded for Towns, both delivered standout performances. Randle posted his first triple-double as a Timberwolf with 19 points, 11 rebounds, and 10 assists, while DiVincenzo went nuclear from deep, hitting six threes and finishing with 25 points.

Head coach Chris Finch has to be pleased with how this retooled lineup has gelled, even without star guard Anthony Edwards, who has missed four games with a hamstring injury but could return Wednesday. The Timberwolves have maintained their offensive tempo and defensive effort, showing no drop-off despite the roster shuffle.

Randle’s versatility has unlocked new lineup combinations, giving Minnesota a more fluid offensive look. DiVincenzo’s perimeter shooting has been the perfect complement, keeping defenses honest and spreading the floor. If Edwards returns, the Wolves gain a huge scoring boost against one of the East’s stingiest home defenses.

NBA Prediction & Betting Angle

This matchup feels personal, a true “trade-measuring” game between two contenders who swapped stars and are thriving in new systems. The Knicks’ home-court edge and defensive stability give them the upper hand, especially with Towns dominating the paint and leading their balanced attack.

Expect both teams to push the pace early before New York’s depth and interior presence take control late.

Final Score:  Knicks 117, Timberwolves 109
Lean:  New York -4.5
Total: 
Under 229.0 

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