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Ole Miss (6-1) at Oklahoma (6-1)
- When: Oct 25 2025, 12:00 PM
- Where: Gaylord Family Oklahoma Memorial Stadium, Norman, OK
- Where to watch: ABC
- Last Meeting: Ole Miss 26-14, October 26th, 2024
(8) Ole Miss vs (13) Oklahoma Preview & Prediction
Spread: Oklahoma -5.0
Moneyline: Oklahoma (-200)
Total: 52.5
Ole Miss Rebels: Air Raid and Attitude
Lane Kiffin brings his No. 8 Ole Miss Rebels into Norman with one of the most explosive offenses in the nation. Ole Miss is averaging more than 300 passing yards per game and ranks among the country’s top ten in total offense. Quarterback Trinidad Chambliss continues to deliver with sharp decision-making, piling up 1,549 passing yards and eight touchdowns to just one interception.
The offensive line has quietly been one of the most efficient in college football, allowing only seven sacks all season. That protection has given Chambliss time to hit his deep threats downfield, which could be a major factor against an Oklahoma secondary that thrives on aggressive coverage.
Defensively, Ole Miss remains inconsistent — they can light up the scoreboard but also give up big plays, as shown in last week’s 43-35 loss at Georgia. Kiffin has spent the week emphasizing focus and execution, especially on third downs. The off-field chatter about his rumored interest in the Florida job hasn’t rattled the locker room, with players insisting their attention is locked on Norman.
Oklahoma Sooners: Defense Sets the Tone
While Ole Miss brings flash, Oklahoma counters with force. Head coach Brent Venables has turned the Sooners’ defense into a nightmare for opponents, leading the nation in total defense (213 yards per game) and sacks (4.0 per game). The Sooners are also No. 1 in tackles for loss, averaging nearly 11 per contest — a sign that Venables’ blitz-heavy schemes are firing on all cylinders.
Oklahoma’s lone stumble came in a 23-6 defeat to Texas, but the Sooners bounced back with a 26-7 win over South Carolina last week. Their defense dictated the game from start to finish, and they’ll need that same energy to slow down Chambliss and the Rebels’ vertical attack.
On offense, Oklahoma’s unit remains efficient if unspectacular, methodical drives, balanced play-calling, and avoiding turnovers have been their calling card. Expect the Sooners to control tempo and field position with their power running game and defensive front.
Final Score Prediction & Betting Outlook
The Rebels’ offense will land a few big punches early, but Oklahoma’s defense has the personnel and pressure packages to take control late. Venables’ disciplined scheme should frustrate Chambliss enough to force mistakes, allowing the Sooners to pull away in the fourth quarter.
Final Score: Oklahoma 31, Ole Miss 23
Lean: Oklahoma -5.0
Total: Over 52.5
- NCAA Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
