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Steelers vs Chargers Betting Odds, Picks & Expert Prediction

NFL preview with Steelers vs Chargers odds, spread and expert betting prediction for Sunday night’s matchup.

(Photo by Getty Images) Justin Herbert
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Pittsburgh (5-3-0) at LA Chargers (6-3-0)

  • When: Nov 9 2025, 8:20 PM
  • Where: SoFi Stadium, Inglewood, CA
  • Where to watch: NBC/Peacock
  • Last Meeting: PIT 20-10, September 22nd, 2024

Pittsburgh vs LA Chargers Preview & Prediction

Spread: LA Chargers -2.5
Moneyline: LA Chargers (-154)
Total: 45.0

Los Angeles Chargers Betting Outlook

The Chargers enter Sunday night at 6-3 and fighting to keep pace in the AFC playoff race, but their offensive line is suddenly in shambles. Losing both Rashawn Slater and Joe Alt has forced Justin Herbert to adjust behind a patchwork unit. Herbert remains composed despite the chaos, preaching focus and resilience as Los Angeles turns to a rotation of Trey Pipkins III, Austin Deculus, Jamaree Salyer, and newly acquired Trevor Penning to fill the gaps.

Penning, traded from New Orleans at the deadline, barely had time to unpack before taking snaps at both tackle spots. The Chargers will need immediate chemistry up front to keep Herbert upright against one of the NFL’s most disruptive pass rushes. Even with protection issues, the Chargers’ offense continues to find ways to move the ball, and Herbert’s ability to extend plays could be key against Pittsburgh’s pressure-heavy defense.

Los Angeles is a narrow 2.5-point favorite, and this matchup feels like one where Herbert will have to shoulder the load. The passing game should open up late if he gets enough time to throw.

Player Prop Pick: Justin Herbert Over 1.5 Passing Touchdowns – His efficiency in red-zone situations remains strong despite O-line troubles.

Pittsburgh Steelers Betting Outlook

The Steelers are 5-3 and rediscovering their identity on defense. After a rocky start to the year, Mike Tomlin’s crew bounced back with five sacks and six takeaways in last week’s 27-20 win over the Colts. T.J. Watt and Alex Highsmith wreaked havoc on the edges, forcing multiple turnovers and energizing a defense that looked lost just two weeks ago.

With DeShon Elliott out, Pittsburgh simplified its coverage schemes, letting Jalen Ramsey and new addition Kyle Dugger settle into defined safety roles. That clarity showed immediate results, with corner Joey Porter Jr. noting the defense’s improved discipline. On offense, Aaron Rodgers continues to steady the unit with sharp reads and controlled aggression. Though the Steelers lack a true WR2, Rodgers has distributed the ball to nine different touchdown scorers this season, spreading defenses thin.

Pittsburgh knows a full-strength Herbert is dangerous, his 382-yard, 90-rushing-yard performance against them in 2021 still stings. But Tomlin’s team is better structured now, built to capitalize on protection breakdowns and win the turnover battle.

Player Prop Pick: T.J. Watt Over 0.75 Sacks – Facing an inexperienced tackle rotation, he’s primed to make an impact.

Expert Betting Outlook & NFL Prediction

This matchup comes down to the trenches. The Chargers’ offensive line instability makes life difficult for Herbert, while the Steelers’ rejuvenated pass rush could tilt momentum. However, Los Angeles has the more reliable quarterback and home-field edge. Expect a gritty, low-scoring affair where Herbert’s composure wins out late.

Final Score:  Chargers 24, Steelers 20
Lean:  LA Chargers -2.5
Total: 
Uder 45.0 

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