San Francisco (5-6-0) at Buffalo (9-2-0)
- When: Dec 1 2024, 8:20 PM
- Where: Highmark Stadium, Orchard Park, NY
- Where to watch: NBC
Game Odds, Spread, Moneyline & Total
San Francisco 49ers @ Buffalo Bills
Moneyline
San Francisco 49ers +235
Buffalo Bills -285
San Francisco 49ers @ Buffalo Bills
Point Spread
San Francisco 49ers 6.5 (-115)
Buffalo Bills -6.5 (-105)
San Francisco 49ers @ Buffalo Bills
Total
Over 44.5 (-110)
Under 44.5 (-110)
- Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
Key Players:
San Francisco: Brock Purdy
Buffalo: Josh Allen
Team Stats
| 49ers | Bills | |
| 5-6 | Record | 9-2 |
| 2-3 | Away & Home | 5-0 |
| 4-7-0 | ATS | 7-4-0 |
| 6-5-0 | O/U | 7-4-0 |
Last Matchup:
BUF 34-24, December 7th, 2020
Game Preview
Bills vs. 49ers: Betting Preview for Snowy Showdown in Buffalo
The San Francisco 49ers, coming off back-to-back losses, are desperate to turn their season around as they travel to Buffalo to face the red-hot Bills in a Sunday night matchup. Despite injuries and challenges, star running back Christian McCaffrey remains optimistic, stating, “Our team is hungry. We still have everything in front of us.”
But will that hunger translate into covering the spread against the surging Buffalo Bills (9-2), who are heavy favorites with snow in the forecast?
49ers’ Struggles and Injury Woes
San Francisco (5-6) has dropped two straight and now faces the daunting task of heading east for the third time in four weeks. Injuries continue to pile up, with key players like Nick Bosa and Trent Williams ruled out. Brock Purdy, recovering from a shoulder issue, is expected to start, but the Niners are thin on both sides of the ball.
McCaffrey’s return has yet to pay dividends for the 49ers’ offense. The star running back has averaged just 3.5 yards per carry in his last three games, a far cry from his 5.4 average in 2023. While the 49ers rank second in the NFL in rushing attempts, their inability to sustain drives has been a glaring issue.
On defense, missed tackles have been costly. Against the Packers, San Francisco allowed 83 of Josh Jacobs’ 106 rushing yards after contact. Fred Warner, nursing a broken bone in his ankle, emphasized the need for team tackling, especially with Buffalo’s explosive offense on deck.
Bills: Rested, Rolling, and Ready
The Bills, winners of six straight, are firing on all cylinders. Coming off a bye week, they boast the league’s No. 1 scoring offense, averaging over 30 points in each of their last five games. Quarterback Josh Allen continues his MVP-caliber season, with Buffalo poised to clinch its fifth consecutive AFC East title.
Buffalo’s defense also gets a boost with the expected return of linebacker Matt Milano, who has missed significant time due to injury. The defense’s ability to force mistakes and stifle opposing rushing attacks could be the difference, especially in the snowy conditions forecasted for Sunday.
The Bills are well-versed in playing through lake-effect snow, with three major storms impacting games in the last two years. For San Francisco, this will be an entirely new challenge.
Betting Insights and Pick
The Bills opened as 6.5-point favorites, and with good reason. They’re rested, healthy, and accustomed to the Buffalo weather. The 49ers, meanwhile, are banged up, traveling across the country, and facing a brutal environment.
Key betting trends:
– 49ers: 0-3 ATS in their last three games.
– Bills: 5-1 ATS in their last six home games.
– Over/Under: With lake-effect snow in play, the total could hinge on whether the 49ers can get anything going offensively. Buffalo’s defense ranks in the top 10 in points allowed, and a low-scoring game might favor the under.
Pick: Back the Bills -6.5 to cover. Their offensive firepower, defensive resurgence, and home-field advantage in the snow make them the clear choice. If you’re feeling bold, also the under on total points could be worth a look, given San Francisco’s offensive struggles and the weather conditions.
NFL Parlay Picks & Predictions
Final Score: Buffalo 26-17
The Pick: Buffalo -6½ (-105) & Under 44½
A $100 Parlay Bet will return $300
- NFL Odds source: Bovada Sportsbook
