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San Francisco (0-0-0) at Seattle (0-0-0)
- When: Sep 7 2025, 4:05 PM
- Where: Lumen Field, Seattle, WA
- Where to watch: FOX
- Last Meeting: SEA 20-17, November 17th, 2024
Can Seattle’s New QB Avoid Seeing Ghosts Again
Spread: San Francisco -1.5
Moneyline: San Francisco -123
Total: 43.5
The Setup: Seahawks’ House of (Not-So-Much) Pain
Once upon a time, Lumen Field was where opponents came to watch their playoff hopes drown in a sea of neon-green noise. Then 2023 happened, and the Seahawks basically became the world’s worst Airbnb hosts: 3-6 at home, dropping six of their last seven in Seattle. Ouch.
Veteran defensive lineman Jarran Reed summed it up best: “We have to win at home.” Translation: please stop embarrassing us in front of the neighbors.
Seahawks 2.0: New Faces, Same Noise
Seattle’s offseason was basically one giant garage sale. Geno Smith? Off to Vegas. DK Metcalf? Packed up for Pittsburgh. Tyler Lockett? Shipped to Tennessee. What did they get in return? Sam Darnold, who is on his fourth attempt at being “the guy,” and Cooper Kupp, who at least knows how to catch footballs when healthy.
Kupp admitted he used to hate visiting Seattle, but now he’s excited to make Lumen his turf. (Hopefully his hamstrings agree.) The question is whether Darnold can avoid looking like Darnold. Seahawks bettors better pray.
The 49ers: Still Dangerous, Still Weird
The 49ers made the Super Bowl just two years ago, but last season was uglier than a bad Thanksgiving casserole. At 6-11, they managed to tumble into the NFC West basement.
But optimism is back! Brock Purdy’s elbow isn’t hanging by a thread, George Kittle isn’t limping, and Christian McCaffrey… well, sort of. He’s questionable with a calf, which feels like a bad joke since he already missed 13 games last year. Without him, this offense could look less like a Ferrari and more like a used Prius.
Still, Nick Bosa and the defense look juiced (in the good, legal way). Their young guys are buzzing, and defensive coordinator Robert Saleh is back to make life miserable for quarterbacks, especially the turnover-prone ones. Hi, Sam.
The Coaching Chess Match
This isn’t just a game; it’s a nerd-off. Kyle Shanahan, the offensive wizard who probably dreams in play-action concepts, goes head-to-head with Mike Macdonald, a defensive mad scientist. Shanahan respects the scheme but also called it “conservative,” which is like saying your boss “means well” before roasting him behind his back.
Expect Shanahan to scheme up quick passes to cover McCaffrey’s uncertain status, while Macdonald will be dialing up blitzes like he’s spinning a roulette wheel.
Prediction: The Grind in the Rain
Seattle’s crowd will make noise, Kupp will get some catches, and Darnold will throw at least one “what was that?” interception. The 49ers’ defense will be the difference, even if their offense sputters without McCaffrey.
Final Score: 49ers 23, Seahawks 20
Lean: PICK_HERE
Total: PICK_HERE
- NFL Football Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
