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Seattle (2-1-0) at Arizona (2-1-0)
- When: Sep 25 2025, 8:15 PM
- Where: State Farm Stadium, Glendale, AZ
- Where to watch: Amazon Prime Video
- Last Meeting: SEA 30-18, December 8th, 2024
Seattle vs Arizona Preview & Expert Prediction
Spread: Seattle -1.5
Moneyline: Seattle (-130)
Total: 43.5
Arizona Cardinals Betting Outlook
The Cardinals enter Thursday at 2–1, but their slim loss to San Francisco exposed how difficult life will be without James Conner. His season-ending foot injury leaves Trey Benson to shoulder the rushing attack, and that’s a huge ask for a young back.
Kyler Murray still gives Arizona a fighting chance. The defense has carried much of the load, holding opponents to just 17 points per game (fifth-best in the NFL). Big-money acquisition Josh Sweat and veteran Calais Campbell have both been difference-makers, combining for four sacks and game-changing plays.
That said, history isn’t on Arizona’s side, the Seahawks have beaten them seven straight times since 2021. Playing spoiler in Arizona requires another strong defensive effort and finding ways to manufacture offense without Conner.
Cardinals Player Prop Pick: Kyler Murray Over 1.5 Passing Touchdowns – with the run game diminished, expect Murray to lean heavily on the air attack.
Seattle Seahawks Betting Outlook
Seattle has strung together two straight wins and looks sharper each week. Sam Darnold has surprised, completing over 70% of his throws while staying upright behind an improved offensive line. While the run game remains an issue, rookie wideout Tory Horton has burst onto the scene, giving Darnold another explosive target.
The Seahawks’ defense has been as advertised. Their run-stopping unit is elite, holding teams to just 3.2 yards per carry, and they’ve spread the wealth in pressuring quarterbacks, ten different players have logged tackles for loss already. Byron Murphy II, their 2024 first-rounder, is quickly developing into a disruptive force inside.
Seattle is favored by 1.5, with momentum, the matchup tilts in their direction. Their aerial efficiency might be enough to overcome Arizona’s stingy defense.
Seahawks Player Prop Pick: Sam Darnold Over 224.5Passing Yards – his accuracy and limited sacks allowed suggest continued success through the air.
NFL Prediction & Betting Angle
Bovada have Seattle as a slight 1.5-point favorite with a total of 43.5. This NFC West clash has defensive grit written all over it, but the Seahawks’ passing efficiency and home-field edge could make the difference. Expect a hard-fought divisional battle that comes down to the final quarter, with Seattle just barely covering in a game that hovers around the total.
Final Score: Seahawks 23, Cardinals 20
Lean: Seattle -1.5
Total: Under 43.5
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
