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SMU vs No. 22 Louisville NCAA Football Betting Odds & Picks

SMU and Louisville will both be gunning for a victory when they meet at L&N Federal Credit Union Stadium.

(Photo by Getty Images) Tyler Shough

Game: SMU Mustangs vs Louisville Cardinals

Date: Saturday, October 5, 2024

Location: L&N Federal Credit Union Stadium in Louisville, KY

TV: ESPN

Odds/Point Spread: Cardinals (-6.5)

Total/Over-Under: 55.5

The SMU Mustangs (4-1) will face off against the Louisville Cardinals (3-1) at L&N Federal Credit Union Stadium on Saturday, October 5, 2024. SMU enters the game as 6.5-point underdogs according to Bovada oddsmakers. The over/under is set at 55.5.

SMU comes into this game with a 4-1 record for the season. In their last game, they defeated the Florida State Seminoles with a score of 42-16. SMU had a strong rushing performance with 204 yards gained on 51 attempts, averaging 4.0 yards per carry. They accumulated a total of 458 yards on 74 plays. Defensively, the Mustangs allowed 222 passing yards and 63 rushing yards in the game.

 

SMU has gained a total of 2,097 yards this season, scoring 20 touchdowns. They have given up the ball 7 times and have been penalized 38 times for a total of 377 yards. The Mustangs average 205.6 rushing yards per game and score an average of 42.2 points per game.

On defense, SMU allows 21.4 points per game and has given up 444 rushing yards and 1,112 passing yards so far this season. They have surrendered 10 passing touchdowns and 4 rushing touchdowns.

The Cardinals hold a 3-1 record for this season. In their last game, they were defeated by the Notre Dame Fighting Irish with a score of 31-24. Louisville rushed for 131 yards and gained a total of 395 yards in the game.

Louisville averages 475.5 total yards per game, with 178.5 rushing yards and 297.0 passing yards per game. They score an average of 41.5 points per game while allowing 16.0 points per game defensively.

Will the Mustangs cover the 6.5-point spread against the Cardinals tonight?

Free Pick: Take the SMU Mustangs +6.5

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