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St. Louis (78-80) at San Francisco (77-81)
- When: Sep 24 2025, 9:45 PM
- Where: Oracle Park, San Francisco
- Where to watch: FDSMW
Cardinals vs Giants – Game Preview & Expert Predictions
Moneyline: St. Louis -112
Total: 8.0
RunLine: St. Louis -1.5 (+165)
St. Louis Cardinals Breakdown
The Cardinals (78–80) staged a stunning comeback Tuesday, erasing a five-run deficit to beat San Francisco 9–8 and officially end the Giants’ postseason hopes. While their own chances of sneaking into the wild card are razor thin, they’re still battling to finish strong.
Sonny Gray (14-8, 4.33 ERA) takes the mound with some personal milestones in sight. The veteran is chasing his first 15-win season since 2015 and sits just six strikeouts shy of the 200 mark. He’s been solid against the Giants historically, going 4-1 with a 3.18 ERA in eight starts, though oddly enough this will be his first career outing in San Francisco.
Gray has won two straight decisions and would love to extend that streak while keeping the Cardinals’ faint playoff heartbeat alive. Expect him to attack a Giants lineup that’s now playing for pride.
Cardinals Player Prop Pick: Sonny Gray Over 6.5 Strikeouts – he’s close to a milestone and has the matchup to chase it.
San Francisco Giants Breakdown
The Giants (77–81) had their playoff dreams crushed Tuesday, and now they’re left to play out the string at Oracle Park. Manager Bob Melvin admitted the elimination hit hard, but the team will look to salvage something in the series finale.
JT Brubaker (0-0, 3.65 ERA) gets the surprise start after being acquired late in the season. Used mostly in relief this year, he’s struggled historically against St. Louis with an 0-6 record and a 6.20 ERA in nine appearances. That track record doesn’t inspire much confidence against a Cardinals team that just erupted for nine runs.
The offense showed fight Tuesday, but with little left to play for and their rotation depleted, San Francisco faces an uphill climb against a motivated Gray.
Giants Player Prop Pick: Heliot Ramos Over 1.5 Total Bases – Ramos has been one of San Francisco’s bright spots, showing power and gap-hitting ability that makes him a strong candidate to deliver extra-base production in this matchup
MLb Prediction & Betting Outlook
With Gray hunting personal milestones and the Giants turning to Brubaker, the edge leans heavily toward the Cardinals. Motivation and matchup both favor the road team. St. Louis keeps their slim playoff chances alive while San Francisco’s struggles continue in the aftermath of elimination.
Best Bet: St. Louis (-112)
Toral: Over 7.5 Alt Lines (-125)
Final Score Prediction: Cardinals 5, Giants 3
- MLB Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
