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USC (8-2) at Oregon (9-1)
- When: Nov 22 2025, 3:30 PM
- Where: Autzen Stadium, Eugene, OR
- Where to watch: CBS
- Last Meeting: Oregon 36-27, November 11th, 2023
(15) USC vs (7) Oregon Preview & Prediction
Spread: Oregon -10.5
Moneyline: Oregon (-439)
Total: 59.5
Oregon Ducks Betting Breakdown
Oregon rolls into this matchup looking every bit like a team with real College Football Playoff intentions. The Ducks crushed Minnesota last week and have covered spreads with ease thanks to a balanced, relentless attack. The return of tight end Kenyon Sadiq boosted their passing game, and getting wideout Dakorien Moore back could elevate things further.
Freshman Jordon Davison keeps punching in touchdowns, while Noah Whittington’s burst has helped Oregon maintain one of the most efficient ground games in the country. With their defense holding opponents to just under 14 points per game, the Ducks have the ingredients to control pace and make USC chase all afternoon.
Oregon Player Prop to Consider: Jordon Davison Anytime Touchdown Scorer – His goal-line usage has been automatic lately.
USC Trojans Betting Breakdown
USC arrives in Eugene with everything on the line. The Trojans pulled out a gritty comeback win in brutal weather last week, and their passing game continues to be the saving grace of their season. Makai Lemon and Ja’Kobi Lane have developed into one of the nastiest receiver tandems in the conference, and Jayden Maiava leads the Big Ten in passing by volume and consistency.
Where USC gets into trouble is on defense. They’ve held second-half opponents down recently, but those were offenses nothing like Oregon’s. Expect the Trojans to throw early and often to avoid running into Oregon’s brick-wall run defense.
USC Player Prop to Consider: Makai Lemon Over 93.5 Receiving Yards – Oregon can be attacked through the air, and USC will lean on its WR1 all game.
Expert Prediction & Betting Angle
Oregon’s firepower, efficiency, and home-field advantage give them the edge, but USC’s passing attack keeps this one entertaining. Over bettors should be wide awake for this matchup.
Final Score: Oregon 38, USC 27
Lean: Oregon -10.5
Total: Over 59.5
- NCAA Football Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
