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D-backs vs Padres MLB Baseball Odds & Expert Picks

Arizona and San Diego will meet on the field at PETCO Park in a battle of division rivals.

(Photo by Getty Images) Randy Vásquez
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Arizona (46-47) at San Diego (49-43)

  • When: Jul 10 2025, 9:40 PM
  • Where: PETCO Park, San Diego
  • Where to watch: SDPA

Diamondbacks vs Padres – Game Preview, Prediction and Player Props

Moneyline: Arizona -116
Total: 8.5
RunLine: Arizona -1.5 (+140)

Arizona Diamondbacks Outlook

The Diamondbacks are hovering below .500, and it’s easy to point fingers at the underwhelming rotation. But you wouldn’t know it watching their current series in San Diego. Arizona’s big three, Gallen, Kelly, and Pfaadt have each delivered strong outings, with two wins already in the books.

The Snakes mashed four homers on Wednesday and Brandon Pfaadt twirled a career-best 8 innings of two-run ball. Now, they aim to snatch the series win behind Eduardo Rodriguez (3-5, 5.78 ERA). Yes, his last outing was a meltdown (9 runs in 4.1 IP), but history is on his side: he’s thrown 11 2/3 shutout innings vs the Padres lifetime.

D-Backs Prop Picks:

Lourdes Gurriel Jr – Over 1.5 Total Bases – Gurriel is slugging north of .500 in July and has 3 multi-hit games in his last 4. He’s got power and a good matchup here.

Ketel Marte – To Record a Hit – Marte’s plate discipline has been sharp, and Vasquez’s shaky command sets him up nicely for a productive night.

San Diego Padres Outlook

The Padres haven’t quite recaptured their early-season magic. Scoring has dried up, they’ve topped four runs in just 3 of their last 16 games. That puts extra pressure on Randy Vasquez (3-4, 3.79 ERA), who has been solid but often walks a tightrope. In 21+ career innings vs Arizona, he’s been effective, but command remains a concern (42 BB in 90 IP this season).

Padres Prop Picks:

Fernando Tatis Jr. – Over 0.5 Home Runs – Tatis has launched two homers this series and looks locked in vs left-handers like Rodriguez.

Luis Arraez – Over 1.5 Hits – The contact king continues to rack up base knocks and is one of the few Padres with consistent at-bats.

Game Prediction & Betting Lean

The D-backs’ bats are hot, and Rodriguez might just bounce back against a limp Padres lineup. If Vasquez can’t limit damage, the Padres’ thin offense may not keep up. Their inconsistency makes them a tough bet right now.

Final Score Prediction: Arizona 6, San Diego 4
Lean: Arizona (-116)
Total: 
Over 8.5 (-120) 

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