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Arizona (72-74) at San Francisco (74-71)
- When: Sep 10 2025, 3:45 PM
- Where: Oracle Park, San Francisco
- Where to watch: ARID
Diamondbacks vs. Giants – Game Betting Preview & Prediction
Moneyline: San Francisco -112
Spread: San Francisco -1.5 (+165)
Total: 8.5
San Francisco Giants Betting Outlook
The Giants (74-71) are riding one of their hottest stretches of the season and enter this matchup looking to complete a sweep at home. Their bats have been relentless, blasting seven home runs in the first two games of the series. Patrick Bailey led the surge with two long balls, while Jung Hoo Lee, Dominic Smith, Matt Chapman, Heliot Ramos, and Willy Adames also joined the home-run parade.
San Francisco’s power surge isn’t just a two-game fluke. The Giants have won 13 of their last 16 games overall, with seven victories in their past eight at Oracle Park. Adames summed it up best: confidence is soaring, and the clubhouse is loose as the offense continues to roll.
The Giants will look to keep swinging against Eduardo Rodriguez, who enters with a 7-8 record and a 5.22 ERA. San Francisco tagged him for four runs back in May, and lifetime he’s struggled against them, posting a 6.14 ERA across three starts. Though Rodriguez is coming off strong outings against the Dodgers and Red Sox, he’ll be tested by a lineup locked in at the plate.
Arizona Diamondbacks Betting Outlook
The Diamondbacks (72-74) find themselves in freefall after what had looked like a turnaround. They’ve dropped five straight, erasing the momentum of a four-game winning streak that briefly had them over .500. Sitting 4.5 games behind the Mets in the wild-card race, their postseason hopes are slipping fast.
Arizona will face rookie Carson Seymour (1-2, 4.25 ERA), who they got to earlier this season when he allowed four runs in three innings of relief. James McCann and company went deep on him in that July meeting, and the D-backs will hope for a repeat. Seymour, however, showed promise in his latest outing, holding St. Louis to just one run over five innings in a road win.
The Diamondbacks’ offense has gone cold at the worst possible time, managing just eight runs across their last four games. Unless they spark early against Seymour, the Giants’ red-hot bats could bury them again.
Betting Outlook & Prediction
The Giants are rolling at the plate, while Arizona is sliding out of contention. Rodriguez has pitched better lately, but his track record against San Francisco and the Giants’ current power surge are tough to overlook.
San Francisco rides its home-run wave to finish the sweep, tightening the wild-card race while Arizona’s playoff chances fade further.
Score Prediction: Giants 6, Diamondbacks 4
Pick: San Francisco (-112)
Total: Over 8.5 (-103)
- MLB Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
