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Orioles vs Cubs MLB Baseball Odds & Parlay Picks

Baltimore and Chi. Cubs will meet on the field at Wrigley Field in a battle of interleague teams.

(Photo by Getty Images) Colin Rea
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Baltimore (51-60) at Chi. Cubs (64-46)

  • When: Aug 3 2025, 2:20 PM
  • Where: Wrigley Field, Chicago
  • Where to watch: Marquee Sports Network-Chicago

Orioles vs. Cubs – Game Betting Preview & Prediction

Moneyline: Chi. Cubs -185 
Spread: Chi. Cubs -1.5 (+120)
Total: 8.0

Baltimore Orioles Betting Preview

Baltimore sends rookie right-hander Brandon Young to the mound as he continues searching for his first major league win. Young (0-5, 6.63 ERA) showed clear progress in his last outing, going six innings and allowing just two runs against a powerful Blue Jays lineup. It was his first official quality start, and the Orioles went on to win that game 3-2.

Despite the encouraging outing, Young has had his struggles at the big-league level. While his control has improved—throwing 61 of 86 pitches for strikes in his last start—he still gives up too much contact and hasn’t shown consistent swing-and-miss stuff. He’s yet to face the Cubs, and pitching at Wrigley could pose another test for the 26-year-old.

Baltimore’s offense has been inconsistent throughout the series, and with the rubber match on the line, they’ll need to offer run support early to ease the pressure on their rookie. Though the team has shown flashes, their chances hinge heavily on whether Young can replicate his Toronto outing or regress to early-season form.

Chicago Cubs Betting Preview

The Cubs are looking to bounce back after a 4-3 loss on Saturday, despite a strong debut from trade acquisition Willi Castro, who had a single, a triple, and scored twice. Chicago still holds the edge in this series and sends Colin Rea to the hill for the finale.

Rea (8-5, 4.25 ERA) started July strong but has stumbled recently, giving up a combined 10 earned runs across his last two starts. Still, his previous numbers against the Orioles are promising: 2.53 ERA with two no-decisions, suggesting he can limit damage when facing this particular lineup.

At home and backed by a stronger bullpen and deeper offense, the Cubs are in a solid spot to rebound. If Rea can limit early trouble and keep the Orioles’ bats quiet, Chicago should have the tools to take this game comfortably.

Prediction

The Cubs have the pitching edge in terms of experience, and Baltimore’s rookie starter is still unproven despite a strong showing last time out. Chicago’s lineup is deeper and more consistent at home, giving them the upper hand in this rubber match. Chicago covers the runline with a bounce-back win, while the total sneaks just over in a steady offensive performance.

Score Prediction: Cubs 6, Orioles 3
Pick:   Chi. Cubs -1.5 (+120)
Total: Over 8.0 (-111)  

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