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Yankees vs Orioles Odds, Prediction & Betting Preview

Betting breakdown for Yankees vs Orioles with odds, spread, and score prediction.

(Photo by Getty Images) Cam Schlittler
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Baltimore (75-85) at NY Yankees (92-68)

  • When: Sep 27 2025, 1:05 PM
  • Where: Yankee Stadium, Bronx
  • Where to watch: YES

Orioles vs. Yankees – Game Betting Preview & Prediction

Moneyline: NY Yankees -227 
Spread: NY Yankees -1.5 (-115)
Total: 9.0

New York Yankees Betting Outlook

The Yankees are finishing the season with their best surge at the perfect time, chasing the Blue Jays in a razor-thin AL East race. After Friday’s 8-4 win, New York has rattled off six straight victories and nine of their last 10.

The Bronx Bombers were exactly that in the opener. Giancarlo Stanton crushed two homers and drove in five runs, while Aaron Judge added another blast to remind everyone why Yankee Stadium feels like a nightly home run derby. When Judge and Stanton homer in the same game, history says New York wins, they’re now 51-7 in those matchups.

Rookie starter Cam Schlittler gets the ball and has quietly been steady. With a 3.27 ERA and 11 of 13 starts allowing three or fewer runs, he has provided much-needed reliability in the back half of the rotation. New York has gone 6-1 in his last seven outings, making him a betting favorite to keep the Yankees rolling.

Baltimore Orioles Betting Outlook

The Orioles are limping toward the finish line, going 4-7 against the Yankees this year and dropping six of the last seven. In Friday’s loss, Jordan Westburg gave Baltimore a momentary spark with a three-run blast, and Tyler O’Neill followed with a solo shot, but the O’s couldn’t cash in when it mattered, stranding 10 runners and going just 1-for-10 with men in scoring position.

Tomoyuki Sugano takes the mound for the second straight start against New York, and that’s not exactly good news for Baltimore bettors. The rookie has allowed four or more runs in five of his last six starts, with his ERA ballooning to 6.49 in that stretch. His previous outing against the Yankees lasted just three innings, capped by Stanton’s milestone 450th career homer.

MLB Betting Outlook & Prediction

The Yankees are locked in, the bats are booming, and Schlittler has been dependable. The Orioles, meanwhile, are scuffling both at the plate and on the mound. New York’s playoff push stays alive, while Baltimore looks ready to turn the page to next season.

Score Prediction: Yankees 7, Orioles 3
Pick: NY Yankees -1.5 (-115)
Total: Over 9.0 (+101) 

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