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Chi. Cubs (86-64) at Pittsburgh (65-86)
- When: Sep 16 2025, 6:40 PM
- Where: PNC Park, Pittsburgh
- Where to watch: SportsNet PT
Cubs vs. Pirates – Game Betting Preview & Prediction
Moneyline: Pittsburgh -125
Spread: Pittsburgh -1.5 (+160)
Total: 7.0
Chicago Cubs Betting Outlook
The Cubs (86–64) are surging at the right time, winning five of their last six to strengthen their grip on a wild-card spot. Their young star on the mound, Cade Horton (10–4, 2.70 ERA), has been one of the breakout arms of the season.
Horton didn’t even make the Opening Day roster but has been exceptional since being called up in May. He’s particularly turned it on after the All-Star break, delivering six starts of at least five scoreless innings. His efficiency has been key, often working around a 75-pitch limit but still dominating opponents — including five no-hit frames against Atlanta earlier this month.
Against Pittsburgh, Horton has already proven capable, blanking them over 5 2/3 innings back in June. The Cubs are hoping he can replicate that performance to push them closer to locking down their playoff spot.
Pittsburgh Pirates Betting Outlook
The Pirates (65–86) have endured a rough stretch, dropping nine of their last ten, but Tuesday brings the return of their ace. Paul Skenes (10–9, 1.92 ERA) will toe the rubber, and few pitchers in baseball command as much respect as the reigning NL Rookie of the Year.
Skenes has been electric all season, racking up 203 strikeouts, second-most in the league. He’s blanked opponents for at least five innings in six post-All-Star break starts, including his last two. His combination of velocity and command makes him one of the toughest arms to solve.
The last time Skenes squared off with Horton, it was a duel for the ages. Both pitchers kept the scoreboard clean before Pittsburgh eventually won in extra innings. Expect Skenes to once again give the Pirates a fighting chance, even as their offense struggles to provide support.
Prediction & Betting Angle
MyBookie Oddsmakers have Pittsburgh as the moneyline favorite at -125, with the total set at 7.0 runs. This matchup screams pitcher’s duel, and the under is certainly in play given the track records of both arms.
The Cubs have momentum and a lineup that has been producing timely power, while the Pirates are riding their ace in hopes of halting their slide. This one projects to be tight, but Pittsburgh’s edge at home with Skenes gives them the slight advantage.
Score Prediction: Pirates 3, Cubs 2
Pick: Pittsburgh (-125)
Total: Under 7.0 (-112)
- MLB Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
