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Cubs vs Cardinals MLB Baseball Odds & Expert Picks

Divisional bragging rights will be on the line when Chi. Cubs and St. Louis meet at Busch Stadium.

(Photo by Getty Images) Matthew Boyd

Chi. Cubs (46-33) at St. Louis (44-36)

  • When: Jun 25 2025, 7:45 PM
  • Where: Busch Stadium, St. Louis
  • Where to watch: FDSMW

Cubs vs Cardinals – Game Preview, Prediction and Player Props

Moneyline: Chi. Cubs -140
Total: 9.0
RunLine: Chi. Cubs -1.5 (+120)

St. Louis Cardinals

The Redbirds have spent the last two nights launching moon-shots at Wrigley’s expense, racking up seven long balls and back-to-back wins (8-2, 8-7). Winners in seven of their last eight, they’ve trimmed the division gap to just 2½. RHP Erick Fedde (3-6, 3.54 ERA) hasn’t tasted victory in seven straight outings and owns a 6.33 ERA in four career starts vs. Chicago.

Nolan Gorman, Lars Nootbaar, Masyn Winn and Brendan Donovan have combined for five homers and 13 RBIs in the series.

Cardinals Prop Picks

Nolan Gorman 2+ Total Bases – his pull power is sizzling.
Masyn Winn to Score a Run – hitting ahead of the bash brothers, he’s crossed five times in two nights.

Chicago Cubs

The North Siders have sprung a leak, surrendering 54 runs in their last six (1-5). They’ll try to halt the bleeding behind a southpaw who’s been quietly steady. LHP Matthew Boyd (6-3, 2.84 ERA) has five straight outings of two earned runs or fewer and a 2.12 ERA in three career starts vs. St. Louis.

Boyd exited his last start after taking a comebacker off the shoulder but is cleared to go. The bullpen adds RHP Porter Hodge (back from the IL), while Ben Brown heads to Triple-A for a tune-up.

Cubs Prop Picks

Ian Happ Over 1.5 Total Bases – eight homers in June, slugging .573 this month.
Matthew Boyd Over 4.5 Strikeouts – Cardinals whiff 24 % vs. lefties, Boyd averaging a punch-an-inning.

Betting Insight & Prediction

Boyd’s form plus a Cardinals lineup due for a cooldown suggests Chicago squares the series in a lower-scoring clash, 5-3.

Final Score Prediction: Cubs 5, Cardinals 3
Lean: Chi. Cubs RL+1.5 (+120)
Total: 
Under 9.0 (-115) 

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