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Red Sox vs Guardians Betting Preview, Odds and Prediction

Expert Red Sox vs Guardians betting breakdown with odds, moneyline, total and score prediction for Monday’s matchup.

(Photo by Getty Images) Brayan Bello
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Cleveland (68-67) at Boston (76-62)

  • When: Sep 1 2025, 1:35 PM
  • Where: Fenway Park, Boston
  • Where to watch: CLEG

Guardians vs. Red Sox – Game Betting Preview & Prediction

Moneyline: Boston -154 
Spread: Boston -1.5 (+135)
Total: 8.5

Boston Red Sox Betting Outlook

The Red Sox finally found a jolt of energy after stumbling through back-to-back losses against Pittsburgh. On Sunday, Jarren Duran turned Fenway into a highlight reel with an inside-the-park, three-run homer that snapped a tie and carried Boston to a much-needed 5-2 victory. The play wasn’t just a spark, it was a lifeline for a team struggling to string together runs at home.

Manager Alex Cora admitted the lineup had been grinding through a slump, missing key bats and failing to produce more than three runs in five straight home games. But Boston has quietly been one of the American League’s hottest clubs since July 1, posting the best record in that stretch (34-18).

The bullpen also got a boost with Aroldis Chapman’s contract extension through 2026, which seems fitting as the flamethrower has been untouchable, 27 saves and 15 consecutive hitless appearances.

On the mound Monday will be Brayan Bello (10-6, 2.99 ERA), who has been reliable of late with wins in four of his last five decisions. Bello pitched 6 2/3 sharp innings against Baltimore in his last outing and has handled Cleveland well in limited action (1-0, 3.27 ERA in two starts).

Cleveland Guardians Betting Outlook

Cleveland comes into Boston after a rollercoaster stretch of play, six straight losses, followed by four straight wins, then a flat 2-0 loss to Seattle on Sunday. At 4 games back in the Wild Card chase, urgency is setting in.

The Guardians’ offense has been erratic, often struggling to produce beyond Steven Kwan’s consistency at the top. Daniel Schneemann’s two-run homer Sunday was one of the few bright spots during their recent skid, but manager Stephen Vogt made it clear: two hits won’t cut it in a playoff race.

Their best chance Monday rests with rookie left-hander Parker Messick (1-0, 0.66 ERA), who has impressed in his first two big-league starts. He’s allowed just one run over 13 2/3 innings, striking out 12 while pounding the zone with elite command. Catcher Bo Naylor praised Messick’s poise and aggressiveness, noting the 24-year-old doesn’t let moments overwhelm him.

MLB Final Betting Outlook & Prediction

The Red Sox have momentum, home-field advantage, and Bello’s consistency on the hill. Cleveland’s rookie lefty has been outstanding, but facing Boston’s lineup on the road is a different test.

This matchup shapes up as a battle of pitching vs timely offense. If the Guardians can’t manufacture runs, the edge goes to Boston, who’s been the more complete team over the past two months.

Score Prediction: Red Sox 5, Guardians 3
Pick: Boston -1.5 (+135)
Total: Under 8.5 (-111) 

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