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Denver (1-0-0) at Indianapolis (1-0-0)
- When: Sep 14 2025, 4:05 PM
- Where: Lucas Oil Stadium, Indianapolis, IN
- Where to watch: CBS
- Last Meeting: DEN 31-13, December 15th, 2024
Indy and Denver Keep Living in #18’s Shadow.
Spread: Denver -1.5
Moneyline: Denver (-125)
Total: 43.0
Indianapolis Colts: Trying Not to Trip Out of the Gate
For once, the Colts didn’t open the season looking like they were still in preseason mode. Coach Shane Steichen turned training camp into a wrestling match disguised as practice, and the results showed, Indy scored on every single possession in their 33-8 thrashing of Miami. That’s the kind of stat that sounds fake until you check twice.
Daniel Jones (yes, that Daniel Jones) looked sharp, the defense forced turnovers like they were handing out free samples at Costco, and rookie tight end Tyler Warren turned heads in his debut. The big question: can Indy’s line hold up against a Denver pass rush that treats quarterbacks like piñatas?
Prediction if Colts keep the tempo: Indy hangs tough, but the offensive line might get shredded.
Denver Broncos: Sacks, Surtain, and Second Chances
Denver enters Week 2 as the favorite at -1.5, and for good reason: their defense is nasty. Six sacks last week reminded everyone why they led the league with 63 a season ago. Oh, and Patrick Surtain II just happens to be the reigning Defensive Player of the Year, good luck throwing his way.
The offense? Well, Bo Nix had three turnovers and still somehow won. That’s like locking your keys in the car but discovering you left the sunroof open. Denver needs fewer “oops” moments and more steady drives, or Indy might sneak one.
Still, with Nik Bonitto turning into a quarterback’s recurring nightmare, Denver’s defense might win this game outright.
Prediction if Broncos limit mistakes: Denver covers and holds Indy under 20.
Gambling Angle & Score Call
MyBookie has Denver -1.0 with a total at 43.5. Translation: the oddsmakers expect a low-scoring, grind-it-out brawl. The Colts have momentum, but Denver’s defense is the trump card here.
Final Score: Broncos 23, Colts 17
Lean: Denver -1.0
Total: Under 43.5
- NFL Football Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
