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Detroit (1-1-0) at Baltimore (1-1-0)
- When: Sep 22 2025, 8:15 PM
- Where: M&T Bank Stadium, Baltimore, MD
- Where to watch: ABC/ESPN
- Last Meeting: BAL 38-6, October 22nd, 2023
Detroit vs Baltimore Preview & Prediction
Spread: Baltimore -4.5
Moneyline: Baltimore (-230)
Total: 53.5
Detroit Lions Betting Outlook
The Lions head into Baltimore with confidence after a 52–21 dismantling of the Bears, piling up 511 total yards. Jared Goff looked sharp, tossing five touchdowns, while rookie wideout Isaac TeSlaa continues to impress with highlight-reel grabs that have quickly earned his quarterback’s trust.
Defensively, Detroit is counting on a healthy Aidan Hutchinson to energize a unit that collapsed last postseason. Hutchinson already has a sack in just two games back and has his eyes set on Lamar Jackson a daunting challenge against one of the NFL’s most elusive quarterbacks. Safety Brian Branch remains a Swiss Army knife, capable of blitzing, covering, and forcing turnovers, making Detroit’s defense less predictable than a season ago.
Still, the Lions have their hands full. The secondary will be under pressure against Baltimore’s explosive attack, and consistency will be key if they want to hang within the spread.
Lions Player Prop Pick: Jared Goff Over 1.5 Passing Touchdowns – Detroit will need to throw to keep pace.
Baltimore Ravens Betting Outlook
The Ravens boast one of the league’s most dangerous offensive duos in Lamar Jackson and Derrick Henry, even though the ground game sputtered to just 45 yards against Cleveland. That didn’t matter much, as Jackson shredded the Browns for four passing touchdowns. When the run isn’t there, Baltimore has proven it can still score in bunches.
This matchup against Detroit offers a prime stage and history favors them. John Harbaugh’s Ravens are nearly unbeatable under the lights at home, sitting at 22-3 in prime-time games. Jackson himself has been flawless on Monday nights, with 22 touchdowns and zero interceptions in nine appearances. Baltimore’s defense, after a shaky opener against Buffalo, rebounded with a 41-17 win over Cleveland, but now faces a tougher test against Detroit’s balanced offense.
Ravens Player Prop Pick: Lamar Jackson Over 18.5 Total Completions – prime-time history suggests he’ll deliver through the air.
NFL Prediction & Betting Angle
The Ravens are listed as 4.5-point favorites, with the total at 53.5. Baltimore’s track record in prime-time home games is hard to ignore, and Jackson’s spotless Monday night résumé adds another edge. The Lions can score, but their defense has yet to prove it can slow down elite offenses and Baltimore fits that category. Expect fireworks on both sides, but Baltimore’s big-game experience should carry the day.
Final Score: Ravens 31, Lions 24
Lean: Baltimore -4.5
Total: Over 53.5
- NFL Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
