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Houston (58-42) at Arizona (50-51)
- When: Jul 22 2025, 9:40 PM
- Where: Chase Field, Phoenix
- Where to watch: SCHN
Astros vs Diamondbacks – Game Preview, Prediction and Player Props
Moneyline: Houston -123
Total: 8.0
RunLine: Houston -1.5 (+135)
Houston Astros Betting Outlook
The Astros are looking to ride the momentum from rookie Brice Matthews’ breakout performance as they aim to secure the series in Arizona. Matthews, who had been quiet since his call-up, exploded with two home runs and five RBIs in Monday’s 6-3 win, proving he can bring some much-needed firepower to Houston’s injury-depleted lineup.
Veteran ace Framber Valdez (10-4, 2.75 ERA) gets the ball, and he enters Tuesday with a dominant nine-game winning streak. Despite being snubbed for the All-Star Game, Valdez has been lights out since early May and continues to lead Houston’s rotation with consistency. In his last start, Valdez struck out 10 and allowed just an unearned run over six innings before exiting due to a calf bruise from a hard liner. He’s cleared and ready to roll in Phoenix.
Player Prop Pick – Houston:
Jose Altuve to record 2+ total bases – Altuve has owned Eduardo Rodriguez in past matchups, going 9-for-24 with two home runs, making him a strong bet to keep the pressure on Arizona’s pitching.
Arizona Diamondbacks Betting Outlook
The Diamondbacks had their four-game winning streak snapped Monday, dropping them back under .500 and further behind in the NL wild-card race. Eugenio Suarez is doing everything he can to carry the offense, blasting his fifth home run in three games, and he now leads the National League with 36 bombs.
Arizona sends left-hander Eduardo Rodriguez (3-6, 5.94 ERA) to the mound. Rodriguez had shown signs of turning things around in June, but July has been a nightmare, surrendering 13 runs and 20 hits in just 8 1/3 innings over his last two starts. Facing Houston is a tough assignment, as he’s 1-7 with a bloated 7.51 ERA in 11 career starts against the Astros.
Player Prop Pick – Arizona:
Eugenio Suarez to hit a home run – With his current power surge, Suarez is the most dangerous bat in the lineup and a clear threat to take Valdez deep.
Game Prediction & Betting Lean
The Astros have the edge with Valdez on the mound, especially against a shaky Rodriguez and a D-backs team that struggles against Houston’s lineup depth. Matthews’ spark plus Altuve’s success against Rodriguez tilt this game in Houston’s favor.
Final Score Prediction: Astros 6, Diamondbacks 3
Lean: Houston (-123)
Total: Over 8.0 (-116)
- MLB Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
