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No. 8 Iowa State vs No. 5 Houston College Basketball Odds & Picks

The Big 12 conference rival Iowa State and Houston are set to renew hostilities when they meet at Fertitta Center.

(Photo by Getty Images) L.J. Cryer

Iowa State (21-5) at Houston (22-4)

  • When: Feb 22 2025, 2:00 PM
  • Where: Fertitta Center, Houston, TX, USA
  • Where to watch: ESPN

Game Preview

Houston Favored by 12, Total Set at 131

No. 5 Houston (-12) looks to keep its winning streak alive Saturday, but No. 8 Iowa State comes in riding a four-game heater of its own. With the total set at 131, this Big 12 showdown could test Houston’s elite defense against Iowa State’s balanced attack.

The Cougars (22-4, 14-1) have been road warriors, setting a Big 12 record with their 12th straight road win after dismantling Arizona State 80-65. However, they return home, where they’ve been just as dominant, outscoring conference foes by an average of 17.8 points per game.

“It’s a remarkable feat,” Houston coach Kelvin Sampson said about the road streak. “Winning 12 in a row in this league means you’ve got mentally tough and talented players. This is something people will remember about this program.”

Houston’s defense has been elite, holding opponents to a national-best 57.6 PPG. The Cougars have crushed teams like BYU, Kansas State, and Utah by 30+ points, proving they’re the team to beat in the Big 12.

Key Players:

LJ Cryer (14.5 PPG, 40.8% from deep) leads the Cougars’ scoring attack.

J’Wan Roberts (11.6 PPG, 6.4 RPG) anchors the interior.

Milos Uzan (10.3 PPG, 4.9 APG) provides playmaking stability.

Iowa State (21-5, 11-4) thrives on depth and balance. The Cyclones have won their last four by double digits, including a 79-65 win over Colorado on Tuesday. Coach TJ Otzelberger’s squad relies on an eight-man rotation with five double-digit scorers, making them tough to defend.

“We emphasize balance,” Otzelberger said. “Our depth means we don’t rely on just one guy to carry the load.”

Key Cyclones:

Curtis Jones (17.2 PPG) leads the team despite coming off the bench.

Keshon Gilbert (14.1 PPG) provides a scoring punch.

Joshua Jefferson (12.8 PPG, 7.9 RPG) controls the glass.

Betting Breakdown:

Spread: Houston -12

Total: 131

Trends: Houston’s defense has been dominant, but Iowa State’s balance and depth make them a dangerous underdog. The Cyclones have covered in seven of their last ten, while Houston’s ability to lock down opponents keeps games under the total more often than not.

Prediction:

Houston’s defense should set the tone, but Iowa State’s depth makes them a live underdog. Look for the Cyclones to keep it competitive, with the Cougars pulling away late.
Lean: Iowa State +12, Under 131.

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