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Dodgers vs Diamondbacks Odds & Betting Preview

Handicappers break down Dodgers vs Diamondbacks with odds, analysis, and score prediction for Thursday’s matchup

(Photo by Getty Images) Yoshinobu Yamamoto
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LA Dodgers (89-69) at Arizona (80-78)

  • When: Sep 25 2025, 3:40 PM
  • Where: Chase Field, Phoenix
  • Where to watch: ARID

Dodgers vs. Diamondbacks – Game Betting Preview & Prediction

Moneyline: LA Dodgers -169 
Spread: LA Dodgers -1.5 (-105)
Total: 8.5

Los Angeles Dodgers Betting Outlook

The Dodgers keep finding new ways to win, this time leaning on a creative bullpen shuffle that helped them squeeze out a 5–4, 11-inning victory Wednesday night. With that result, Los Angeles now sits just one win (or one Padres loss) away from clinching its 12th NL West title in the last 13 seasons.

Thursday’s finale is lined up perfectly for them: Yoshinobu Yamamoto (11-8, 2.58 ERA) takes the ball in what could be the clincher. The right-hander has been locked in lately, posting a 1.76 ERA across his last six starts and allowing just three hits total in his last three outings. Against the Diamondbacks, he’s been tough as well, owning a 2.30 ERA in five career starts. Corbin Carroll in particular has had no answers, going just 1-for-14 against him.

With Yamamoto rolling and the Dodgers bullpen finding late-season form with Clayton Kershaw, Roki Sasaki, and Jason Wrobleski all contributing in key spots, Los Angeles is in prime position to secure the division crown in Phoenix.

Arizona Diamondbacks Betting Outlook

The Diamondbacks nearly pulled off back-to-back stunners but fell just short in extras on Wednesday. At 80–78, they’re still alive for the final NL wild-card spot, trailing the Mets by one game. However, with Cincinnati owning the tiebreaker and the Padres looming, Arizona’s path requires near perfection.

Instead of Zac Gallen, Arizona will use a bullpen combination for this critical game. Jalen Beeks (5-2, 3.67 ERA) will serve as the opener, with Nabil Crismatt (3-0, 2.61 ERA) handling the bulk innings. Crismatt has been serviceable in his role, tossing five scoreless innings against Minnesota in his last start before shifting back to relief. His history against the Dodgers is modest—12 appearances, all in relief, with a 3.71 ERA.

The problem for Arizona is depth. A bullpen game against Yamamoto is not the matchup they wanted with the season on the line. They’ll need timely hitting and another strong showing from Corbin Carroll and Ketel Marte to stay afloat.

MLB Prediction & Betting Angle

Los Angeles has all the momentum, the better starter, and the clear advantage in the matchup. Arizona’s bullpen game makes the underdog play risky, even with playoff urgency. Los Angeles celebrates the NL West title in Phoenix, while Arizona’s wild-card hopes grow slimmer heading into their weekend set.

Score Prediction: Dodgers 5, Diamondbacks 3
Pick: LA Dodgers -1.5 (-105)
Total: Under 8.5 (-108) 

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