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LSU (0-0-0) at Clemson (0-0-0)
- When: Aug 30 2025, 7:30 PM
- Where: Memorial Stadium, Clemson, SC
- Where to watch: ABC
- Last Meeting: LSU 42-25, January 13th, 2020
(9) LSU vs (4) Clemson Preview & Prediction
Spread: Clemson -4.0
Moneyline: Clemson -192
Total: 57.5
Clemson Tigers Betting Outlook
Clemson enters 2025 with national title aspirations and plenty of continuity at quarterback. Cade Klubnik is now in his fourth season and has developed into one of the nation’s most reliable signal callers. Last year he piled up 3,639 yards with 36 touchdown passes, giving the Tigers a consistent aerial attack that finally got them back into the CFP. While Clemson hasn’t won a national title since 2018, Dabo Swinney’s squad is favored to repeat as ACC champions and looks poised to push further in the playoff race this time.
The Tigers’ defense remains physical in the trenches, but it’s Klubnik’s growth that makes Clemson dangerous. The staff’s patience in developing him has paid off, and he now enters the season as one of the Heisman contenders.
Player Prop to Watch (Clemson): Cade Klubnik Over 1.5 Passing Touchdowns — Klubnik should be given plenty of chances to attack an LSU defense still adjusting after turnover in its secondary.
LSU Tigers Betting Outlook
For LSU, the storyline is about ending their streak of poor openers. Since their 2019 national championship run, LSU has dropped four straight Week 1 games, including last year’s loss to USC. Brian Kelly knows that’s unacceptable, and this offseason he leaned heavily on the transfer portal to build much-needed depth.
Veteran quarterback Garrett Nussmeier is back for his fifth year after throwing for 4,052 yards and 29 touchdowns in 2024. He has stuck with the program despite the modern trend of quarterbacks bouncing around, and his familiarity with LSU’s system gives the Tigers a chance to make noise against Clemson. If Nussmeier can limit turnovers and stay composed in a tough environment, LSU can push this game to the wire.
Player Prop to Watch (LSU): Garrett Nussmeier Over 284.5 Passing Yards — Expect LSU to lean on their quarterback to keep pace in a game that could tilt into a shootout.
CFB Prediction & Betting Angle
The line has Clemson listed as 4.0-point favorites, with the total set at 57.5. MyBookie Oddsmakers clearly expect a competitive battle between two top-10 teams with proven quarterbacks. Clemson has the more stable roster and a defensive edge, while LSU is hoping offseason additions can elevate them to early-season success.
Both teams have quarterbacks capable of putting up big numbers, which could tilt this toward the over. However, Clemson’s consistency and the home-field edge in their version of “Death Valley” give them the upper hand.
Final Score: Clemson 34, LSU 28
Lean: Clemson -4.0
Total: Over 57.5
- NCAA Football Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
