- This page contains affiliate links. We may earn a commission at no extra cost to you.
LSU (4-0) at Mississippi (4-0)
- When: Sep 27 2025, 3:30 PM
- Where: Vaught-Hemingway Stadium, Oxford, MS
- Where to watch: ABC
- Last Meeting: LSU 29-26, October 12th, 2024
(4) LSU vs (13) Mississippi Preview & Prediction
Spread: Mississippi -2.5
Moneyline: Mississippi (-120)
Total: 57.0
LSU Tigers: Defense Finding Its Bite
LSU rolls into Oxford unbeaten at 4-0, and the backbone of that record is a defense finally living up to the hype. Ranked top-10 nationally in scoring defense (just 9.25 points allowed per game) and 17th in total yards allowed, Brian Kelly’s revamped unit looks sharp.
Last year, LSU barely escaped Ole Miss at home, but this trip comes with a defense built to travel. After struggling offensively through the first three games, the Tigers finally exploded for 56 points last weekend. That spark could give them needed momentum in this crucial SEC showdown.
Ole Miss Rebels: High-Octane Offense
Lane Kiffin’s Rebels are firing on all cylinders offensively, averaging 543 yards per contest (9th nationally) and nearly 45 points a game. Their lightning tempo forces defenses to stay on their heels, and LSU will face its toughest offensive test yet.
Quarterback health remains a storyline. Starter Austin Simmons is battling an ankle injury, leaving Trinidad Chambliss to shine in relief. Chambliss tallied over 400 combined yards against Tulane, showcasing Ole Miss’ depth at the most important position. At home, the Rebels have history on their side, having edged LSU in Oxford two years ago in a wild 55-49 thriller.
Betting Outlook and Prediction
This matchup is a gambler’s delight: an elite LSU defense meets one of the nation’s most explosive offenses. Ole Miss’ uptempo attack will put pressure on LSU’s defensive front, but the Tigers’ playmakers should keep them close. The series has produced back-to-back nail-biters, and this one feels destined for the same.
Final Score: Ole Miss 32, LSU 27
Lean: Ole Miss -2.5
Total: Over 57.0
- NCAA Football Odds source: Bovada Sportsbook
- Get real-time live scores & latest betting odds here!
