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Brewers vs Cubs Betting Preview, Odds and Expert Prediction

Expert handicapper breakdown of Brewers vs Cubs with moneyline odds, analysis, and final score prediction.

(Photo by Getty Images) Jacob Misiorowski
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Milwaukee (79-47) at Chi. Cubs (72-54)

  • When: Aug 20 2025, 8:05 PM
  • Where: Wrigley Field, Chicago
  • Where to watch: FDSWI

Brewers vs Cubs – Game Preview, Prediction and Player Props

Moneyline: Milwaukee -112
Total: 7.0
RunLine: Milwaukee -1.5 (+155)

Milwaukee Brewers Betting Outlook

Milwaukee enters as the slim -112 moneyline favorite, with the total set at 7.0 runs. After rattling off 14 straight wins, the Brewers have suddenly cooled, dropping three of their last four. Now, they turn to rookie sensation Jacob Misiorowski (4-1, 3.89 ERA), who is looking to rebound from his worst outing of the year when he was roughed up by Cincinnati. The 23-year-old’s electric stuff has already made him a fan favorite, but his command and composure will be key in a divisional battle on the road.

Brewers Prop Pick: Jacob Misiorowski Over 5.5 Strikeouts — Chicago has been strikeout-prone, and Misiorowski has fanned hitters at an impressive clip when his delivery is in sync.

Chicago Cubs Betting Outlook

The Cubs pulled off a crucial doubleheader sweep on Tuesday, cutting into Milwaukee’s division lead and proving they’re still a serious wild-card contender. Willi Castro provided the spark with a homer in Game 1 and a clutch defensive play in Game 2, though his bat has struggled overall since being acquired. Chicago sends Colin Rea (9-5, 3.99 ERA) to the mound, who has been steady but hasn’t fared well against Milwaukee historically, holding an 8.59 ERA in two career starts. The Cubs will need a strong outing from him to keep momentum rolling.

Cubs Prop Pick: Willi Castro to Record a Hit — after breaking through Tuesday, this could be the confidence boost he needs to find consistency at the plate.

MLB Prediction & Betting Angle

Momentum is leaning Chicago’s way, but Milwaukee has the better arm on the mound in Misiorowski. Expect a low-scoring duel where the bullpens decide the outcome.

Final Score Prediction: Brewers 4, Cubs 3
Lean: Milwaukee (-112)
Total: 
Over 6.5 Alt Lines (-135) 

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