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Milwaukee (95-61) at San Diego (85-71)
- When: Sep 22 2025, 9:40 PM
- Where: PETCO Park, San Diego
- Where to watch: FDSWI
Brewers vs Padres – Game Preview, Prediction and Player Props
Moneyline: San Diego -123
Total: 7.0
RunLine: San Diego -1.5 (+165)
Milwaukee Brewers Betting Outlook
The Brewers enter this series already celebrating their division crown, clinched Sunday despite a loss in St. Louis. With playoff positioning still in play, Milwaukee sits three games ahead of Philadelphia for the NL’s best record and home-field advantage. Even with momentum, the rotation just took a hit with Brandon Woodruff heading to the IL due to a lat strain.
Freddy Peralta (17-6, 2.65 ERA) will step in to open the set. He’s been one of baseball’s most reliable arms this season, striking out 10 in his last start against the Angels. Peralta has held the Padres in check historically, posting a 2.86 ERA across six appearances.
The Brewers have the talent to spoil San Diego’s playoff clinch plans, but with the division secured, motivation could be a question mark in this series.
Brewers Player Prop Pick: Freddy Peralta Over 7.5 Strikeouts – facing a Padres team that can pile on runs but also whiffs in bunches.
San Diego Padres Betting Outlook
San Diego sits on the verge of a postseason berth and can lock it up with just two more wins. Sunday’s 3-2 victory over the White Sox trimmed the magic number to two, and with Xander Bogaerts set to return from his fractured foot, the timing couldn’t be better. Bogaerts brings experience and balance to the lineup after hitting .262 with 20 steals before going down.
Nick Pivetta (13-5, 2.81 ERA) will take the mound, though his history against Milwaukee is shaky. He’s struggled in four career starts versus the Brewers, giving up runs in bunches. That said, he’s been a stabilizer for San Diego this season, and a quality outing here could help wrap up the playoff spot at home.
San Diego has struggled at times to generate consistent offense without Bogaerts, but his return adds depth as they look to finish strong.
Padres Player Prop Pick: Xander Bogaerts Over 1.5 Total Bases – fresh legs and a return spot boost in a must-win situation.
MLB Prediction & Betting Angle
MyBookie Oddsmakers have San Diego pegged as slight favorites (-123) with the total at 7.0. This looks like a tightly contested matchup, but motivation tilts toward the Padres, who still need wins to clinch while Milwaukee has already locked in the division. Bogaerts’ return gives San Diego an extra spark, and Pivetta should benefit from the urgency of the moment.
The Brewers won’t roll over with Peralta dealing, but San Diego’s situational edge is hard to overlook.
Final Score Prediction: Padres 4, Brewers 3
Lean: San Diego (-123)
Total: Under 7.5 Alt Lines (-135)
- MLB Odds source: MyBookie Sportsbook
- Get real-time live scores & latest betting odds here!
