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Mets vs Padres MLB Baseball Odds & Expert Picks

NY Mets and San Diego will both be trying to pick up a win when they battle at PETCO Park.

(Photo by Getty Images) Dylan Cease
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NY Mets (62-44) at San Diego (57-49)

  • When: Jul 28 2025, 9:40 PM
  • Where: PETCO Park, San Diego
  • Where to watch: SNY

Mets vs. Padres – Game Preview, Prediction and Player Props

Moneyline: San Diego -125
Total: 8.0
RunLine: San Diego -1.5 (+160)

San Diego Padres Betting Outlook

The Padres (53-51) return home fresh off a 9-2 win in St. Louis, closing out a 5-5 road trip with an offensive surge. Their bats exploded for 16 hits in the finale, marking their highest run total since an 11-run outburst against the Dodgers back in June.

The spotlight is on Dylan Cease (3-10, 4.59 ERA), who could be making his final start for San Diego with the trade deadline looming. Cease remains a strikeout machine (144 Ks in 113 2/3 innings), but his season has been marred by costly home runs and inconsistent execution. Against the Mets, he’s struggled historically, going 0-3 with a 6.88 ERA in three career starts.

Padres Player Prop to Watch:
Manny Machado
Over 1.5 Total Bases. Machado’s bat has heated up, and with Cease under pressure, expect him to provide key offense.

New York Mets Betting Outlook

The Mets (57-47) are red-hot, sweeping the Giants over the weekend and grabbing a 1.5-game lead in the NL East. Their pitching staff, bolstered by the recent addition of lefty reliever Gregory Soto from Baltimore, has been sharp, with Soto debuting Sunday by throwing a perfect inning with a strikeout.

Frankie Montas (3-1, 4.62 ERA) will take the mound for New York. While Montas has been inconsistent this season, he is coming off a solid outing against the Angels, going 5 2/3 innings and allowing only two runs. He’s also fared well against the Padres in his career, posting a 1-0 record with a 3.86 ERA in three appearances.

Mets Player Prop to Watch:
Francisco Lindor
Over 1.5 Total Bases. Lindor’s bat has been clutch during New York’s seven-game win streak, and his hot form could continue against Cease.

Game Prediction & Betting Lean

The Padres’ offense is streaky, and Cease’s track record against New York is concerning. With the Mets riding a wave of momentum, they have the edge in a tight matchup.

Final Score Prediction: Mets 5, Padres 3
Lean: NY Mets (+107)
Total: 
Over 7.5 Alt Lines (-130) 

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