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Yankees vs Cardinals Betting Odds, Expert Picks & Preview

Expert betting preview: Yankees vs Cardinals odds, analysis, and predictions with Fried vs Gray showdown.

(Photo by Getty Images) Max Fried
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NY Yankees (65-57) at St. Louis (61-62)

  • When: Aug 16 2025, 7:15 PM
  • Where: Busch Stadium, St. Louis
  • Where to watch: FOX

Yankees vs Cardinals – Game Preview, Prediction and Player Props

Moneyline: NY Yankees -143
Total: 7.5
RunLine: NY Yankees -1.5 (+120)

New York Yankees Betting Outlook

The Yankees keep clawing in the AL Wild Card chase, and Saturday’s spotlight is on Max Fried (12-5, 2.94 ERA). The lefty has been shaky lately, coughing up 24 earned runs across his last seven outings. But history favors him here, he’s a perfect 5-0 with a 1.10 ERA against St. Louis.

New York grabbed a tight 4-3 win Friday, making it three wins in their last four. Another boost could come if Paul Goldschmidt returns to the lineup against his old team after a mild knee scare.

Yankees Prop Pick: Max Fried Over 5.5 Strikeouts – The Cardinals strike out nearly 9 times per game, giving Fried a prime chance to bounce back.

St. Louis Cardinals Betting Outlook

The Cardinals are stumbling at the wrong time, losers of three straight and slipping further behind in the NL Wild Card chase. But Sonny Gray (11-5, 4.06 ERA) has been sharp, yielding only three runs across his last two starts (14 innings). He’s also punched out 15 batters in that stretch while limiting walks, looking every bit like the ace they need.

Gray loves the big stage and gets one here against his former team. He’s 2-2 with a 3.38 ERA in seven career starts against New York. If the Cards want to snap this skid, Gray has to set the tone.

Cardinals Prop Pick: Sonny Gray Under 2.5 Earned Runs – In strong recent form, he’s kept top-tier offenses like the Dodgers and Cubs in check.

MLB Prediction & Betting Angle

The Yankees have the stronger lineup and Fried’s career numbers vs St. Louis are hard to ignore. Still, Gray’s form keeps this one tight.

Final Score Prediction: Yankees 4, Cardinals 3
Lean: Ny Yankees (-143)
Total: 
Under 7.5 (-115) 

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