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Old Dominion vs South Florida Cure Bowl Betting Preview & Pick

Old Dominion vs South Florida betting preview with spread, total analysis, and expert score prediction.

2025 Cure Bowl - Old Dominion vs South Florida
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Old Dominion (9-3) at South Florida (9-3)

  • When: Dec 17 2025, 5:00 PM
  • Where: Camping World Stadium, Orlando, FL
  • Where to watch: ESPN

Old Dominion vs South Florida Preview & Prediction

Spread: South Florida -2.5
Moneyline: South Florida (-146)
Total: 52.5

South Florida Bulls Betting Breakdown

South Florida enters the Cure Bowl chasing a milestone tenth win, but the path looks very different than it did during the regular season. The Bulls will be without the quarterback who powered their offense all year, forcing a late adjustment under center. Still, this roster has enough balance and experience to remain competitive, especially as a short favorite.

Senior Gaston Moore takes over quarterback duties for his final college appearance. While he lacks the dynamic running element of his predecessor, Moore brings familiarity with the system and a steady presence. South Florida is expected to lean more on ball control, short passes, and situational execution rather than explosive plays.

Coaching continuity is another variable. With staff changes already in motion, the Bulls are simplifying responsibilities and focusing on fundamentals. That approach often plays well in bowl games, where preparation and discipline matter more than scheme creativity. Playing in Orlando also provides a slight comfort edge, even if it is technically a neutral site.

From a betting standpoint, South Florida laying 2.5 reflects trust in roster depth and overall season consistency. They have shown the ability to win close games, which is important with a total set at 52.5.

Old Dominion Monarchs Betting Breakdown

Old Dominion arrives with momentum after a strong season but faces similar challenges. Their offense also loses its primary engine, forcing a younger quarterback into the spotlight. The Monarchs are comfortable leaning into the run game and playing physical football, which shortens games and keeps margins tight.

The backup quarterback has already shown he can move the chains with his legs, adding a different wrinkle to the offense. That style fits well in bowl settings, especially against teams adjusting defensively. Old Dominion’s skill position players give them enough firepower to capitalize if South Florida makes mistakes.

As an underdog, the Monarchs profile as a team capable of hanging around for four quarters. Their experience in close games and willingness to grind possessions makes them dangerous if this turns into a low margin contest.

Expert Prediction & Betting Angle

With both teams breaking in new quarterbacks, expect a cautious start and a heavier emphasis on the run. That setup favors a competitive game rather than a shootout. South Florida’s overall balance and familiarity give them a narrow edge late.

Final Score: South Florida 27, Old Dominion 24
Lean: South Florida -2.5
Total: 
Under 52.5 

Super Bowl LX Odds

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