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Eagles vs Chiefs Odds, Picks & Betting Preview

Expert Eagles vs Chiefs betting preview with spread, total, and predictions for Sunday’s NFL showdown.

(Photo by Getty Images) Patrick Mahomes
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Philadelphia (1-0-0) at Kansas City (0-1-0 )

  • When: Sep 14 2025, 4:25 PM
  • Where: GEHA Field at Arrowhead Stadium, Kansas City, MO
  • Where to watch: FOX
  • Last Meeting: PHI 40-22, February 9th, 2025

Philadelphia vs Kansas City Preview & Prediction

Spread: Philadelphia -1.0
Moneyline: Philadelphia (-121)
Total: 47.0

Philadelphia Eagles Betting Outlook

The Eagles enter this rematch with plenty of swagger after dominating Dallas in their opener and riding a 7-game winning streak. Jalen Hurts remains steady, but the big question is whether A.J. Brown rebounds after being virtually invisible last week. Philly’s defense forced Mahomes into one of his worst halves ever in the Super Bowl, and they’ll try to repeat that pressure. With the addition of Tank Bigsby as backfield depth alongside Saquon Barkley, the Eagles look even more dangerous.

Eagles Prop to Watch: A.J. Brown Over 65.5 Receiving Yards. Expect him to bounce back after a shockingly quiet opener.

Kansas City Chiefs Betting Outlook

Patrick Mahomes has been replaying the Super Bowl nightmare in his head all offseason, and now he gets another shot at Philly. The Chiefs’ 27-21 loss to the Chargers exposed some glaring issues, from a thin receiver group to sloppy discipline. With Xavier Worthy, Jalen Royals, and Rashee Rice all likely out, it’s up to Marquise Brown, Travis Kelce, and JuJu Smith-Schuster to carry the load. Kansas City simply can’t afford another 0-2 start.

Chiefs Prop to Watch: Patrick Mahomes Over 1.5 Passing Touchdowns. Even with limited weapons, he’s too competitive to let the offense stall twice in a row.

NFL Expert Prediction:

Philadelphia’s depth and consistency on both sides of the ball give them the edge, even on the road. Kansas City will scrap behind Mahomes, but their roster issues and missing receivers make the difference late.

Final Score: Eagles 27, Chiefs 23
Lean: Philadelphia -1.0
Total: 
Over 47.0 

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