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Padres vs D-backs MLB Baseball Odds & Expert Picks

San Diego and Arizona will meet on the field at Chase Field in a battle of division rivals.

(Photo by Getty Images) Luis Arraez
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San Diego (62-50) at Arizona (53-59)

  • When: Aug 4 2025, 9:40 PM
  • Where: Chase Field, Phoenix
  • Where to watch: SDPA

Padres vs Diamondbacks – Game Preview & Expert Predictions

Moneyline: San Diego -131
Total: 9.0
RunLine: San Diego -1.5 (+130)

San Diego Padres Breakdown

The Padres arrive in Phoenix scorching hot, winners of seven of their last eight and sitting comfortably four games ahead in the NL wild-card race. San Diego’s front office made it clear they’re going all-in, acquiring arms like JP Sears and Mason Miller, plus outfield bats Ramon Laureano and Ryan O’Hearn. With a lineup anchored by Manny Machado and a contact machine in Luis Arraez, the Padres are sending a message: October is the goal.

Lefty JP Sears (7-9, 4.95 ERA) makes his Padres debut after arriving from Oakland. While he’s been inconsistent, he has a knack for limiting damage, and facing an Arizona lineup that just got shuffled might be a good spot. Expect the bullpen to be on call, but San Diego’s balanced offensive attack gives them the edge.

Padres Player Prop Pick: Luis Arraez Over 1.5 Hits — He’s raking at .298 on the year and is 10-for-19 lifetime off Pfaadt.

Arizona Diamondbacks Breakdown

The Diamondbacks finally stopped the bleeding with back-to-back wins over Oakland after dropping nine of ten. General manager Mike Hazen lit a fire under the squad with a team meeting after the trade deadline sell-off. Gone are Merrill Kelly and Eugenio Suarez, opening doors for young guys like Blaze Alexander, who homered Sunday and declared he’s not wasting this shot.

Starter Brandon Pfaadt (10-7, 5.11 ERA) brings a mixed bag. While he leads the D-backs in wins and has pitched well against the Padres (career 3.24 ERA in seven starts), he’s coming off a disaster outing against Detroit. If he keeps it together early, the bats will need to do the rest.

Diamondbacks Player Prop Pick: Ketel Marte Over 0.5 RBI — He’ll be counted on to drive the offense as the clubhouse veteran.

Prediction & Betting Outlook

Padres ride their post-deadline surge to a 6-4 win. Arizona shows some fight, but falls just short in a tight contest. Both starters are volatile, and both lineups have enough pop to cash the over late.

Best Bet: San Diego -1.5 (+130)
ToralOver 9.0 (-120)
Final Score Prediction:
 Padres 6, Diamondbacks 4

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