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Padres vs Reds MLB Baseball Odds & Parlay Picks

San Diego and Cincinnati will both be trying to pick up a win when they battle at Great American Ball Park.

(Photo by Getty Images) Dylan Cease

San Diego (44-36) at Cincinnati (42-39)

  • When: Jun 27 2025, 7:10 PM
  • Where: Great American Ball Park, Cincinnati
  • Where to watch: SDPA

Padres vs. Reds – Game Betting Preview & Prediction

Moneyline: San Diego -135 | Total: 9.0

San Diego Padres Betting Preview

After pushing through a brutal stretch of 26 games in 27 days, the Padres finally caught a breather on Thursday. They return Friday with momentum after a gritty 1-0 win over the Nationals, where Luis Arraez extended his hit streak to 12 games and drove in the game’s lone run. With Fernando Tatis Jr. now anchoring the cleanup spot, the top half of the lineup looks more balanced. Dylan Cease (3-6, 4.43 ERA) gets the start and is coming off a bounce-back outing, allowing just one run over nearly seven innings against the Royals. He’s held the Reds to a 3.00 ERA in two prior starts.

San Diego’s bullpen is also in strong shape despite missing closer Robert Suarez (serving the final game of a suspension). Thanks to a dominant seven-inning effort from Nick Pivetta last time out, the relief corps should be fresh and ready behind Cease.

Cincinnati Reds Betting Preview

Cincinnati saw its three-game win streak snapped with a 7-1 loss to the Yankees but still carries confidence into this home series. Elly De La Cruz remains red-hot with a six-game hitting streak that includes two home runs and six runs scored. However, the offense managed just four hits on Wednesday, highlighting a need for more consistency at the plate.

Nick Martinez (4-8, 4.40 ERA) takes the ball and has been effective out of the bullpen recently, but struggles in starting roles remain a concern. He’s given up six home runs in his last two starts and owns an ugly 6.89 ERA in three career starts vs. San Diego. The Reds will need him to manage the early innings carefully or risk burning through their bullpen too soon.

Final Score Prediction:

San Diego has the edge on the mound, a more stable offense, and a rested bullpen. Both starters are capable of delivering quality starts, and with both bullpens coming in fresh, runs could be limited. San Diego continues its momentum, Cease outduels Martinez, and the Padres take Game 1 on the road.

Score Prediction: Padres 5, Reds 3
Pick: San Diego RL -1.5 (+120)
Total: Under 9.0 (+100) 

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